关键词: 自噬, 种植体周炎, 炎症, 巨噬细胞, 中性粒细胞

Abstract: Peri-implantitis is an inflammatory lesion of the soft and hard tissues surrounding implants，caused by factors such as microbial plaque and occlusal trauma. Its features include mucosal inflammation around the implant，accompanied by bone loss，which could lead to implant instability or loss. Currently，peri-implantitis has become a common biological complication following implant surgery，and understanding its pathogenesis is crucial for clinical prevention and treatment of the disease. Autophagy is a highly conserved lysosomal degradation process associated with biological processes such as bone immunity，microbial infection，inflammation and regeneration. Through this process，cells could digest intracellular proteins and organelles，thereby achieving self-renewal or adapting to environmental changes. Insufficient or excessive activation of autophagy could lead to dysfunction of vascular endothelial cells，neutrophils，gingival fibroblasts，epithelial cells，macrophages，osteoblasts and osteoclasts. The physiological changes in these cells under inflammatory conditions are related to the occurrence and development of peri-implantitis，suggesting that autophagy might play an important role in peri-implantitis. This article provides a review from a cellular perspective on the potential role of autophagy in the pathogenesis and progression of peri-implantitis，aiming to provide potential targets and research directions for the prevention and treatment of peri-implantitis.

Key words: autophagy, peri-implantitis, inflammation, macrophages, neutrophils