关键词: 头颈部肿瘤, 放疗, 骨肉瘤, 病理学

Abstract: Objective    To investigate the clinical and pathological features ，treatment and prognosis of osteosarcoma after maxillofacial radiology. Methods    Retrospective analyze 27 cases of maxillofacial patients with osteosarcoma after radiotherapy from January 2003 to January 2012， in the Fifth Affiliated Hospital of Sun Yat-sen University， describe the time of occurrence， clinical and pathological features and treatment，and follow up the prognosis. Results    Of the 27 patients， 2 patients，because of tumor invasion of the extensive and multiple bone metastases，were inoperable and treated by palliative chemotherapy， but the results were poor，and one year later，they died of lung metastasis and multiple bone metastases. One patient was with lesions involving great range；after comprehensive treatment such as surgery， chemotherapy and radiotherapy， six months later， tumor recurred，and after 1 year he was discovered with lung metastases； several times of chemotherapy proved to be ineffective，and he died in one and a haif  year after operation. The remained 24 cases is relatively limited in the extent of disease， and they received extended surgery resection and chemotherapy；10 cases died in 1 to 2 years after diagnosis，and 12 patients were followed up for 9 months to 5 years without evidence of recurrence，while 2 cases were lost. Conclusion    Osteosarcoma after maxillofacial radiology is of high degree of malignancy， and the prognosis is poor；surgery combined with preoperative and postoperative chemotherapy may improve prognosis.

Key words: head and neck neoplasms, radiotherapy, osteosarcoma, pathology