中国实用口腔科杂志

中国实用口腔科杂志 ›› 2012, Vol. 5 ›› Issue (9): 542-544.

• 论著 • 上一篇    下一篇

银汞合金充填和移除对患者肾功能影响的研究

陈凌，吴赟，汪义永，魏斌
  

  1. 作者单位： 福建医科大学第一临床医学院口腔科，福州  350004 
  • 出版日期:2012-09-15 发布日期:2012-11-24
  • 基金资助:

    基金项目：福建医科大学苗圃科研基金（2010MP013）；福建省教育厅科技项目（2010JA101470）

Study on the effect of silver amalgam filling and removing on patients' renal function

CHEN Ling， WU Yun， WANG Yi-yong， WEI Bin.   

  1. The First Clinical Medical College of Fujian Medical University，Fuzhou 350004， China
  • Online:2012-09-15 Published:2012-11-24

摘要： 目的    探讨银汞合金充填和移除对患者肾功能的影响，进而评价银汞合金充填体的安全性。方法    选择2010年3—10月在福建医科大学第一临床医学院口腔科门诊行口腔健康检查，牙齿有龋坏但未充填的患者24例作为A组研究对象。另选择同期来口腔科门诊就诊，患牙有因龋坏采用银汞合金充填体修复史（2年以上），需更换为复合树脂充填体的患者25例为B组研究对象。对两组患者，分别于银汞合金充填和拆除前及充填和拆除后 1 d、1周、2周、4周、6周、8周收集尿样，检测其尿液中β2-微球蛋白（β2-MG）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、微量白蛋白（mALB）的含量，并进行组内各时点间的比较。结果    （1）两组患者在银汞合金充填和拆除后第1天，尿液中的NAG、β2-MG含量与组内其他各时点的数值比较，差异均有统计学意义（均P < 0.05）；两组内其他各时点间尿液中的NAG、β2-MG含量比较，差异均无统计学意义（均P > 0.05）。（2）两组患者尿液中mALB的含量在银汞合金充填和拆除前后各时点组内比较，差异均无统计学意义（均P > 0.05）。结论    银汞合金使用中的汞释放不会对肾功能产生影响。

关键词: 银汞合金, 微量白蛋白, &beta, 2-微球蛋白, N-乙酰-&beta, -D-氨基葡萄糖苷酶

Abstract: Objective    To explore the effect of silver amalgam filling and removing on　patients' renal function. Methods    The patients were selected in the dental clinic of First Clinical Medical College of Fujian Medical University from March 2010 to October 2010.Oral health checks were carried out；24 patients with caries receiving no filling were selected as group A. At the same time， 25 patients with histories of amalgam restoration longer than 2 years and needing to replace by composite resin restorations were selected as group B. Respectively fill and remove silver amalgam in two groups. Respectively after 1 day， 1 week， 2 weeks， 4 weeks and 8 weeks，collect patients urine， determining the β2-MG，NAG and mALB concentrations in urine and compare. Results    After 1 day in the filling and removing groups NAG andβ2-MG concentrations in urine increased significantly . After 1 week， 2 weeks， 4 weeks and 8 weeks in the filling and removing groups NAG and β2-MG concentrations in urine had non-significant difference from before. Urine mALB in filling and removing groups had non-significant difference between every time point. Conclusion    The mercury release in silver amalgam use won't impact renal function.

Key words: silver amalgam, mALB, &beta, 2-MG, NAG

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