中国实用口腔科杂志

中国实用口腔科杂志

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口腔鳞癌CD147的表达与淋巴转移的关系研究

邱伟 ，孙雷，于霄 ，谭栋东 ，杜启涛   

  1. 大连市口腔医院
  • 收稿日期:2008-06-20 修回日期:2008-07-27 出版日期:2008-08-15 发布日期:2008-08-15

  • Received:2008-06-20 Revised:2008-07-27 Online:2008-08-15 Published:2008-08-15

摘要： 目的 探讨口腔鳞癌组织中黏附分子CD147表达与淋巴转移、临床病理参数之间的关系。方法 将2003年 7 月至2006年12 月大连市口腔医院收治的61例口腔鳞癌患者按有无淋巴结转移、性别、年龄、肿瘤大小及TNM分期进行分组，采用SP免疫组织化学法检测其癌组织中CD147表达情况，对所得数据应用χ2检验、直线相关分析进行统计学处理。结果 口腔鳞癌组织中CD147的阳性率为86.9%;淋巴结转移阳性组CD147表达（93.5%）明显高于淋巴结转移阴性组（80.0%）（P＜0.01）。CD147的表达与患者性别、年龄、肿瘤大小均无显著性相关（r = 0.074、0.173、0.129，均P＞0.05），而与TNM分期显著相关（r = 0.539，P＜0.01），其中随着TNM分期的增高，CD147阳性表达也显著增高。结论 口腔鳞癌可表达CD147，并影响其淋巴结转移。CD147高表达而淋巴结转移阴性的患者有很强的淋巴转移倾向，甚至可能发生淋巴结微转移。

关键词: 口腔鳞状细胞癌, CD147, 淋巴转移

Abstract: Study on the relationship between expression of CD147 and lymphatic metastasis in oral squamous cell carcinomas. QIU Wei*， SUN Lei， YU Xiao， TAN Dong-dong， DU Qi-tao.*Dalian Stomatological Hospital， Dalian 116021， China
Abstract： Objective To explore the relationships between CD147 expression， lymphatic metastasis and clinical pathologic characteristics in oral squamous cell carcinomas （OSCC）. Methods Divide the 61 cases of OSCC into several groups according to lymphatic metastasis， sex， age， tumour size， and TNM stages. Immunohistochemistry SP method was performed to measure the situation of CD147 expression. Chi-square test and linear correlation was applied to do statisticsed processing . Results The percentage of positive CD147 was 86.9% in OSCC. In lymphatic metastasis positive group CD147 positive expression （93.5% ） was significantly higher than that of lymphatic metastasis negative group （80.0%） （P＜0.01）. The CD147 expression did not show any correlation with sex， age， and tumour size （r = 0.074、0.173、0.129，P＞0.05），but showed significant correlation with the TNM stages （r = 0.539，P＜0.01）;as the TNM stages increased，CD147 positive expression became significantly higher. Conclusion OSCC could express CD147， and influence lymphatic metastasis in OSCC. The present results suggest that the patients with increased expression of CD147 without lymphatic metastasis have strong tendency of lymphatic metastasis， and even have possible lymphatic micrometastasis.

Key words: oral squmous cell carcimoma, CD147, lymphatic metastasis