中国实用口腔科杂志 ›› 2023, Vol. 16 ›› Issue (5): 630-634.DOI: 10.19538/j.kq.2023.05.022

• 综述 • 上一篇    下一篇

噬菌体在口腔医学领域的应用研究进展

李忆博1,刘    桢1,罗文欣1,周    丹2   

  1. 1. 口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川大学华西口腔医学院,四川  成都  610044;2. 四川大学华西医院疾病分子网络前沿科学中心呼吸感染与干预研究室,四川  成都  610213
  • 出版日期:2023-09-30 发布日期:2023-11-02
  • 基金资助:
    国家自然科学基金青年基金(32200114)

  • Online:2023-09-30 Published:2023-11-02

摘要: 噬菌体是地球上极为丰富的生命形式,自发现以来为人体健康做出了巨大贡献。口腔是噬菌体在机体中的重要栖息地,口腔噬菌体学是生命科学中噬菌体研究的重要组成部分。随着噬菌体的深入研究和相关技术的发展,噬菌体在口腔医学领域中的应用也越来越广泛,其在机制研究、疾病诊断、感染治疗与预防、预后监测等方面都发挥了重要作用。文章分析了噬菌体在口腔医学领域应用的可能性及价值,并介绍了噬菌体疗法和噬菌体展示技术在口腔医学领域应用的具体实例,总结了最新的一些研究进展,为后续噬菌体用于口腔疾病的预防、诊断及治疗提供借鉴。

关键词: 噬菌体疗法, 口腔噬菌体, 噬菌体展示技术, 口腔医学

Abstract: Phages are extremely abundant life forms on earth and have made great contributions to human health since their discovery. The oral cavity is an important habitat for phages in the organism,and oral phage science is an important part of phage research in life sciences. With the in-depth study of phage and the development of related technologies,the application of phage in the field of dentistry has become more and more extensive,and it plays an important role in mechanism research,disease diagnosis,treatment and prevention of infection,and prognosis monitoring. The article analyzes the possibility and value of phage application in the field of dentistry,and introduces specific examples of phage therapy and phage display technology applied in the field of dentistry. Some recent research progresses are summarized to provide a reference for the subsequent phage use in the prevention,diagnosis and treatment of oral diseases.

Key words: phage therapy, oral phage, phage display technique, stomatology