中国实用口腔科杂志

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成釉细胞瘤的临床及基础研究

黄洪章,陶 谦   

  1. 中山大学光华口腔医学院·附属口腔医院口腔颌面外科
  • 收稿日期:2008-12-26 修回日期:1900-01-01 出版日期:2009-02-15 发布日期:2009-02-15

  • Received:2008-12-26 Revised:1900-01-01 Online:2009-02-15 Published:2009-02-15

摘要:

成釉细胞瘤(ameloblastoma, AM)是常见的良性牙源性肿瘤,具有局部侵袭性,术后容易复发。目前,国内外有关AM的临床研究对指导治疗和预后具有积极意义。有关AM的细胞增殖分化、凋亡、基质降解和破骨等侵袭机制为其研究热点。本文简要概述了近年来对AM的临床病理分型以及侵袭性分子机制的研究进展。

关键词: 成釉细胞瘤, 侵袭, 分子机制

Abstract:

Ameloblastomas (AMs)are common odontogenic epithelial tumors, which are usually considered to be benign. They are locally invasive and easy to recur. The clinical research has a progressive significance in guiding the treatment and prognosis of AMs. The basic research of AMs focused in cell proliferation and differentiation, apoptosis, degradation of ECM and osteoclasia, et al. In this article, we mainly overview the research advances in clinicopathological classification and molecular mechanism of invasion of AMs.

Key words: ameloblastoma, invasion, molecular mechanism