中国实用口腔科杂志

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口底解剖和肿瘤扩散

高璐1赵怡芳2   

  1. 1. 大连医科大学口腔医学院口腔解剖生理学教研室,大连医科大学附属口腔医院综合科,辽宁  大连  116044;2. 武汉大学口腔医学院·口腔医院口腔颌面外科,湖北  武汉  430079
  • 出版日期:2020-06-15 发布日期:2020-09-21
  • 作者简介:高璐,大连医科大学口腔医学院副教授、副主任医师、硕士研究生导师。兼任辽宁省口腔医学会颞下颌关节病学及牙合学专业委员会委员、口腔生物学与病理学专业委员会委员。主要研究方向为口腔颌面部肿瘤发生发展的作用机制、头颈部鳞状细胞癌侵袭和转移的分子机制以及外泌体介导的肿瘤药物靶向治疗。主持及参与国家级科研项目5项,省部级科研项目6项。发表学术论文30余篇,其中SCI收录论文10余篇;主编和参编著作、教材6部。
  • 基金资助:
    国家自然科学基金(81802706);辽宁省自然科学基金(20180550145)

  • Online:2020-06-15 Published:2020-09-21

摘要: 口底癌的侵袭转移与口底的解剖学特点密切相关。口底位于舌下区,具有薄弱的黏膜下层、丰富的淋巴回流和神经血管支配,舌下腺和下颌下腺导管也开口于此,且其与周围组织器官和多个间隙关系密切。口底癌恶性程度较高,早期即可发生周围组织浸润和颈部淋巴结转移。从解剖学的角度认识口底癌的浸润转移特性,将有助于理解该病不同病期的临床表现、制定合理的治疗方案及评估预后。

关键词: 口底癌, 解剖, 侵袭, 淋巴结转移

Abstract: The invasion and metastasis of carcinoma of the floor of mouth(FMC) are closely related to its anatomical features. The floor of the mouth is located in the sublingual area,which is characterized by thin submucosa,multi-directional lymphatic flow and rich neurovascular innervation. The ducts of sublingual and submandibular glands directly open to the oral mucosa and keeps close anatomical relationship with surrounding tissues,organs and the multiple spaces in the maxillofacial region. The cancer of the floor of mouth has a high degree of malignancy, and surrounding organs invasion,peritoneal dissemination and lymphatic metastasis may occur in early FMC. Grasping the invasion and metastasis properties of FMC carcinoma from the perspective of anatomy will help to understand its clinical manifestations at different stage,to make proper treatment and to assess the prognosis of FMC.

Key words: carcinoma of the floor of mouth, anatomy, invasion, lymph node metastasis