关键词: 异病同治, 从脾论治, 牙周炎, 炎症性肠病, 口腔-肠道轴, 脾虚湿热

Abstract: Periodontitis（PD）and inflammatory bowel disease（IBD）are chronic inflammatory disorders located in the oral cavity and gastrointestinal tract，respectively. Recently，more and more evidence has highlighted a significant relationship between them in epidemiology and pathological mechanism，and they have the basis for co-morbidity. Based on the traditional Chinese medicine（TCM）theory of＂treating different diseases with the same method＂，this paper delves into the theoretical framework and modern scientific rationale of＂spleen-oriented therapy＂ in the co-management of PD and IBD. The＂spleen deficiency with dampness-heat＂ may serve as a common core pathogenesis of both conditions，which has been proved in multiple aspects including microbial dysbiosis，Th17/Treg immune imbalance，and dysregulation of signaling pathways such as AHR/STAT1，PI3K/Akt/mTOR，and Nrf2/HO-1. This article reviews the clinical application and pharmacological research advances of representative formulas for fortifying the spleen，clearing heat，and dispelling dampness，including Gancao Xiexin Tang，Shenling Baizhu San，and Fupi Yishen Tang. The findings suggest that such formulas may exert integrated regulating effects by modulating the microbiota-metabolism-immunity network. This review aims to provide a novel perspective for the prevention and treatment of PD and IBD using integrated TCM and Western medicine，contributing to the modernization of TCM research in oral-intestinal co-morbidities.

Key words: treating different diseases with the same method, spleen-oriented therapy, periodontitis, inflammatory bowel disease, oral-gut axis, spleen deficiency with dampness-heat