中国实用口腔科杂志 ›› 2023, Vol. 16 ›› Issue (2): 231-236.DOI: 10.19538/j.kq.2023.02.019
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杨润泽1，2，吴家媛2，周学东3，张亚庆1，王 玮1
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摘要： 外泌体是体内活细胞分泌的一种膜性小囊泡，其良好的生物相容性、稳定性和低免疫原性使其在组织再生领域备受青睐。在牙髓再生过程中，外泌体可通过促进干细胞迁移和分化诱导牙髓组织的新生，但不易长期维持牙髓组织再生的有效浓度。生物支架可对外泌体实现有效包裹，保护其活性且减少流失，通过支架自身降解来缓慢释放外泌体，保证外泌体不断与干细胞接触，诱导牙髓组织的生成。文章就生物支架搭载干细胞来源外泌体在牙髓再生中应用的研究进展做一综述。
关键词: 生物支架, 干细胞, 外泌体, 缓释, 牙髓再生
Abstract: Exosomes are a kind of membranous vesicles secreted by living cells in vivo，and their good biocompatibility，stability and low immunogenicity make them popular in the field of tissue regeneration. During dental pulp regeneration，exosomes can induce dental pulp regeneration by promoting stem cell migration and differentiation. However，it is difficult to maintain the effective concentration of dental pulp tissue regeneration for a long time. Biological scaffolds can effectively encapsulate exosomes，protect their viability and reduce their loss，and slowly release exosomes through the degradation of the scaffold itself，ensuring that exosomes are in constant contact with stem cells and inducing dental pulp regeneration. This article reviews the research progress in application of biological scaffold-encapsulated stem cells-derived exosomes in dental pulp regeneration.
Key words: biological scaffolds, stem cells, exosomes, controlled release, pulp regeneration
杨润泽, 吴家媛, 周学东, 张亚庆, 王 玮. 生物支架搭载干细胞来源外泌体在牙髓再生中应用的研究进展[J]. 中国实用口腔科杂志, 2023, 16(2): 231-236.
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