关键词: 牙周炎, 牙龈卟啉单胞菌, miRNA, Toll样受体

Abstract:

The origin and development of the chronic periodontitis is the result of the pathogenicity of bacteria and the host immune response. The destruction of the periodontal tissue not only depends on the pathogenic role of the bacteria，but is also related to the excessive immunity. In recent years，a class of miRNAs molecules that are not encoding protein is confirmed to play an important role in cell differentiation，organization development，gene regulation and disease control，which prompts that miRNAs may participate in periodontal immune regulation process. In this paper，from the relationship between miRNAs and periodontal immune，we explore the regulatory mechanism of miRNAs in the process of periodontal disease.

Key words: periodontitis, Porphyromonas gingivalis, miRNA, Toll-like receptor