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    02 March 2015, Volume 31 Issue 3 Previous Issue    Next Issue

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    The issues about chemoresistance in cervical cancer.
    LIU Hong,ZHANG Guo-nan.
    2015, 31(3): 198-201.  DOI: 10.7504/fk2015020104
    Abstract ( )   PDF (662KB) ( )  

    Abstract:Cervical cancer is the most common cancer in gynaecological carcinoma. To date, current approved managements continue to rely on the use of surgery, concurrent chemo-radiotherapy, and the chemotherapy is indispensable for high risk disease or metastatic, recurrent advanced lesions. But the chemoresistance hampers the efficacy of available anticancer drugs in treating cervical cancer. So searching biomarkers for predicting the chemosensitivity, explording sensitizer to increase the sensitivity to chemotherapy drugs, and studing new methods to reverse the chemoresistance and targeted-therapies will provide new approaches to the management of the chemoresistant cervical cancer.

    Surgical management of recurrent cervical cancer.
    LI Rui-xin,LIN Zhong-qiu.
    2015, 31(3): 201-203.  DOI: 10.7504/fk2015020105
    Abstract ( )  

    Abstract:The outcome of recurrent cervical cancer is unfavorable. Further managements lying on the condition of recurrence and initial treatments mainly include radiotherapy and surgery. The former is available for local recurrence after primary surgery and para-aortic nodal recurrence,which shows better effects when combined with concurrent chemotherapy. The latter is pelvic exenteration, which can be applied to those after radical radiation, but the patients should be well screened.

    Value of surgery in recurrent platinum-resistance ovarian cancer.
    YANG Zhuo,WANG Dan-bo.
    2015, 31(3): 203-207.  DOI: 10.7504/fk2015020106
    Abstract ( )   PDF (768KB) ( )  

    Abstract:Secondary cytoreductive surgery (SCS) has been given more and more attention in the management of the recurrent platinum-resistance ovarian cancer.More and more studies have demonstrated that selected patients might have favorable outcomes and longer survival interval with optimal secondary cytoreductive surgery.The rationality,feasibility,indications as well as postoperative adjuvant therapy are discussed in the paper.

    Treatment of recurrent and uncontrolled malignant ovarian germ cell tumors.
    YANG Jia-xin,XIANG Yang.
    2015, 31(3): 207-211.  DOI: 10.7504/fk2015020107
    Abstract ( )   PDF (668KB) ( )  

    Abstract:To study the clinical characteristic, the optimal treatments and the prognosis for the recurrent and uncontrolled malignant ovarian germ cell tumors(MOGCT).the few case of recurrent MOGCT were underwent comprehensive surgical staging.And most of them received the non-standard chemotherapy.When the malignant ovarian germ cell tumors were found again, the secondary debulking surgery was done.The former standard chemotherapy for patients was used.The critical treatment is the most important thing for the MOGCT.Even for the recurrence and uncontrolled MOGCT, the satisfied cytoreductive surgery plus the standard chemotherapy also show the significant impact on the prognosis of the recurrence and uncontrolled MOGCT patients.

    The therapeutic role of targeted therapy in the treatment for recurrent platinum-resistant ovarian cancer.
    BAI Ping,SHU Tong,SUN Hui.
    2015, 31(3): 211-216.  DOI: 10.7504/fk2015020108
    Abstract ( )   PDF (687KB) ( )  

    Abstract:Ovarian cancer is noted for high recurrence and poor prognosis.Drug-resistance will eventually appear after repeated intermittent chemotherapy by most patients.There are a number of promising results of targeted therapy in recent clinical trials for patients with platinum-resistant OC.Drugs in extensive research include vascular endothelial growth factor inhibitor,such as Bevacizumab,DNA repair inhibitor,such as Olaparib and Veliparib,angiogenin inhibitor,such as Trebananib,and folate receptor inhibitor,such as Vintafolide,et al.These drugs have recently shown to improve progression-free survival of patients with platinum-resistant OC.Bevacizumab in combination with single-agent chemotherapy was considered as preferred treatment.In this review,the latest developments of targeted therapy in the platinum-resistant recurrent OC are highlighted.

    The role of adjuvant chemotherapy in women with advanced or recurrent resistant endometrial cancer.
    LI Xiao-ping,WANG Jian-liu.
    2015, 31(3): 216-220.  DOI: 10.7504/fk2015020109
    Abstract ( )   PDF (669KB) ( )  

    Abstract:The prognosis of advanced or recurrent resistant endometrial cancer is poor ,and the role of adjuvant chemotherapy has become more and more important.There are many new progress focusing on neoadjuvant chemotherapy, sequential multi-modality adjuvant chemotherapy and radiation, and molecular targeted therapy and so on.Now, paclitaxel combined with carboplatin and anthracycline plus platinum as first line chemotherapy regimen;however,there have been few studies about drug-resistant endometrial carcinoma, and still more samples are needed for clinical trial studies.

    Diagnosis and management of or recurrent resistant gestational trophoblastic neoplasia.
    Lü Wei-guo.
    2015, 31(3): 220-223.  DOI: 10.7504/fk2015020110
    Abstract ( )   PDF (655KB) ( )  

    Abstract:Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 10% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. Various salvage regimens are used worldwide. It is unclear which regimens are the most effective and the least toxic.

    Prognosis evaluation and follow-up of resistant trophoblastic neoplasia.
    ZHAO Jun,XIANG Yang.
    2015, 31(3): 223-226.  DOI: 10.7504/fk2015020111
    Abstract ( )   PDF (654KB) ( )  

    Abstract:Although most patients with gestational trophoblastic neoplasms have optimistic prognosis due to their sensitivity to the chemotherapy, approximately ten to twenty-five percent of them might develop resistance to the primary chemotherapy.The present article gives a brief introduction to evaluating the prognosis and follow-up of the resistant gestational trophoblastic neoplasms.

    The value of tumor markers in prediction of ovarian cancer prognosis.
    CAI Jing, WANG Ze-hua.
    2015, 31(3): 226-229.  DOI: 10.7504/fk2015020112
    Abstract ( )   PDF (655KB) ( )  

    Abstract:A precise prediction of tumor prognosis is essential to promoting the individualized therapy for ovarian cancer. Both protein and non-coding RNA are potential predictive factors, and a series of tumor markers have been proved to be significantly associated with overall survival, progression-free survival and/or response to chemotherapy in patients with ovarian cancer. However, further validations are required before any of the biomarkers can be applied to clinical prediction.

    The association between the polymorphisms of XPG tagSNPs and the clinical outcomes of epithelial ovarian cancer patients treated with platinum-based chemotherapy.
    HU Pei*,KANG Shan*,ZHOU Rong-miao,WANG Na,QI Bing-li*,LI Yan.
    2015, 31(3): 230-234.  DOI: 10.7504/fk2015020113
    Abstract ( )  

    Abstract: Objective To investigate the association of XPG tagSNPs with susceptibility to the platinum chemotherapeutic treatment and survival in epithelial ovarian cancer (EOC) patients.Methods The case retrospective study included 239 ovarian cancer patients.We selected the tagSNPs of XPG gene in Chinese Han population inquired in Hapmap database,and possessed the minor allele frequency (MAF) ≥0.1.The nine tagSNPs (XPG rs1047768,rs2227869,rs4150387,rs17655,rs2296147,rs3759500,rs4150360,rs4150383 and rs751402) were genotyped by allelic specific multiple ligase detection reactions (LDR) method.The clinical outcome parameters included chemotherapy response (TR),progression-free survival (PFS) and overall survival (OS).Results The overall analysis showed that XPG tagSNPs were not associated with the clinical outcomes ovarian cancer.When stratified with the diagnosed age we found that XPGrs1047768C/T and rs2296147C/T polymorphisms were associated with clinical outcomes ovarian cancer patients.For rs1047768C/T polymorphism the C allele was associated with reducing chemotherapy response,PFS and OS in subjects that were older than 50 years of ages(of age TR,OR=0.49,95%CI 0.24~0.98;PFS,HR=0.57; 95% CI 0.38~0.87;OS,HR=0.56; 95%CI 0.34~0.94).Compared with the rs2296147T/T genotype,the C allele was associated with the PFS and OS (PFS,HR=0.63,95%CI 0.41~0.98;OS,HR=0.50; 95%CI 0.28~0.87).Conclusions The XPG rs1047768C/T and rs2296147C/T polymorphisms may play as the markers in predicting the clinical outcomes of ovarian cancer treated with platinum chemotherapy.

    Effects of PKCα,PKCβ and Rho kinase on human uterine contractility in atonic postpartum hemorrhage.
    YAN Jian-ying*,ZHOU Zhi-mei,LIAO Qiu-ping*,CHEN Wen-zhen*,LUO Mei-yu*.
    2015, 31(3): 235-238.  DOI: 10.7504/fk2015020114
    Abstract ( )  

    Abstract: Objective To investigate the effects of Go6976(PKCα/β inhibitor),LY333531(PKCβ inhibitor)and Y-27632(Rho kinase inhibitor)on human uterine contractility in atonic postpartum hemorrhage(PPH). Methods Totally 30 women with atonic PPH as study group and 30 normal pregnant women as control group were included in this study. The myometrial strips from atonic PPH women were adopted to investigate their inhibitory effects by adding Go6976,LY333531 and Y-27632 with isometric tension recording;meanwhile,the effects of LY333531 and Y-27632 on contraction induced by oxytocin were observed following atonic PPH,respectively.Results In study group,the inhibitory effects of Go6976,LY333531 and Y-27632 on amplitude and activity of spontaneous oscillatory contractility were significantly lower than in control group(P<0.05). There was no significance in frequency between two groups(P>0.05).LY333531 and Y-27632 further decreased myometrial strips contraction potentiality induced by oxytocin significantly after PPH(P<0.05). Conclusions PKCα,PKCβ and Rho kinase may be involved in the regulation of myometrial strips contraction,and play an important role in the pathogenesis of atonic PPH.

    Association of autoimmune thyroiditis with ovulation failure.
    XIA Zhou-lan,LU Yue-hong,MA Ying-ying,CHEN Hui-juan.
    2015, 31(3): 239-241.  DOI: 10.7504/fk2015020115
    Abstract ( )  

    Abstract: Objective To investigate the association of autoimmune thyroiditis with ovulation failure. Methods All outpatients with ovulation failure who visited Women and Children’s Hospital of Shaoxing from Jan 2012 to Dec 2013 were enrolled in the study .A total of 196 of them were diagnosed with PCOS and another 152 patients were non-PCOS. Totally 104 patients with normal ovulation whose infertility was caused by husbands at the same period were enrolled as controls. Thyroid function ,thyroid autoantibodies and ultrasound thyroid scan were compared among the three groups. Results Significantly higher prevalence of AIT was detected in PCOS(19.9%) patients when compared to non-PCOS(7.9%) and control group(6.7%)( P<0.05). Moreover there was no difference between non-PCOS and controls (P>0.05). Elevated serum thyrotrophin (TSH), anti-thyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibodies(TgAb) in PCOS were revealed when compared with non-PCOS and controls (P<0.05). The positive rate of ultrasound thyroid scan in all subjects did not differ significantly(P>0.05).Conclusion The prevalence of AIT in PCOS patients are significantly higher than that in ovulation failure patients without PCOS and in controls,which suggests PCOS may be a kind of autoimmune disease and has close association with AIT.

    The clinical analysis of combined multiple surgical methods in treating 37 cases of pelvic organ prolapse.
    SHI Yu-lin,NIU Ju-min,LIU Yan-song.
    2015, 31(3): 242-246.  DOI: 10.7504/fk2015020116
    Abstract ( )  

    Abstract: Objective To analyze the efficacy ,safety and complication of the combination of the traditional surgery with the laparoscopic suspension surgery for pelvic organ prolapse. Methods The present study is a retrospective analysis of the clinical data of 37cases of pelvic organ prolapse receiving surgical treatment in our hospital from September 2007 to December 2012,POP-QⅡ 10cases,POP-QⅢ 19 cases,POP-QⅣ8 cases.All patients underwent the laparoscopic sacral copopexy and traditional vaginal anterior and posterior wall patch,cervical partial amputaton for those 9 patients with cervical extend ,combined laparoscopic sacral ligament fusion,and the round ligament shorten ing with mesh suspension reconstructive pelvic surgery,and 9 patients complicated with severe stress urinary incontinence(SUI) were given transobturator tension-free vaginal tape(TVT-O).Six patients underwent subtotal hysterectomy and 8 patients underwent myomectomy to retain the uterus.The therapeutic effect,the mean operation time,blood loss,time of micturation were observed.Results All the operations were completed successfully.The mean operation time was(153±32)min,the mean blood loss(185.35±58.40)mL ,time of micturation(3.0±1.5)d and ,the follow up duration was 12~53 months.One year of follow-up showed,Aa point -2.4±0.5.Ba point -2.8±0.4,point C -7.5±0.9,Ap point -2.5±0.5 Bp point -2.6±0.4,which were significantly better than that before surgery. All P <0.05. There is no recurrence or erosion and infection or vaginal exposure of path in this group of patients after 1 year.The symptoms of all patients have been alleviated.

    The value of MRI in staging of cervical cancer.
    QIAO Zhi-wei,WANG An-na,WANG Chun-yan,DONG Xue.
    2015, 31(3): 247-250.  DOI: 10.7504/fk2015020117
    Abstract ( )  

    Abstract: Objective To explore the diagnostic value of MRI in the evaluation of para- cervical infiltration, vagina involvement and lymph node involvement in the surgical treatment for patients with cervical cancer. Methods Forty-eight cases receiving surgical treatment were chosen in this study who were first visit patients as cervical cancer .Study the sensitivity, specificity, positive predictive value, negative predictive value, degree of accuracy in the assessment of paracervical infiltration, vagina involvement and lymph node involvement respectively using the postoperative pathology as the gold standard. And surgical - pathologic staging was wsed as gold standard to study the accuracy of MRI staging and preoperative clinical staging.Results For MRI in the surgical treatment of patients with cervical cancer with lymph node metastasis,the sensitivity,specificity, positive predictive value, negative predictive value,degree of accuracy were respectively 65%, 94%, 85%, 83% and 83%,for parametrial invasion the sensitivity,specificity, positive predictive value, negative predictive value, degree of accuracy were respectively 50%,91%,33%,95%,88%, for vaginal invasion the sensitivity, specificity, positive predictive value,negative predictive value,degree of accuracy were respectively 50%,78%,43%,82%,71% .Gynecological examination parametrial invasion in early stage cervical cancer sensitivity、specificity、 positive predictive value、 negative predictive value、degree of accuracy were respectively 0,100%,0、92%,92%,vaginal invasion the sensitivity,specificity, positive predictive value,negative predictive value and degree of accuracy were respectively 75%,100%,100%,92%、94%. The overall clinical staging accuracy was 81%, MRI staging overall accuracy was 67%, and clinical -MRI staging overall accuracy was 92%. Conclusions MRI has a big advantage for cervical cancer with lymph node metastasis;for those with parametrial invasion and vaginal invasion it has good negative predictive value and specificity.The MRI combined with clinical staging is better that the separate use of the two diagnostic methods in improving staging accuracy .

    Analysis of antepartum risk factors of neonatal brain injury.
    GUO Xiao-yue,WANG Yan,SHAO Hui,WEI Yuan,LIU Yun-feng,PIAO Mei-hua,TONG Xiao-mei,ZHAO Yang-yu.
    2015, 31(3): 251-255.  DOI: 10.7504/fk2015020118
    Abstract ( )  

    Abstract: Objective To evaluate the antepartum risk factors of neonatal brain injury.Methods Clinical datas of 351 patients with neonatal brain injury in Peking University Third Hospital from August 2010 to February 2014 were studied retrospectively,287 patients without brain injury in the same period as control group. Data was analyzed by SPSS.Results   Delivery gestational age and  neonatal birth weight(34.0±3.5weeks vs.35.0±2.8weeks,P=0.000;2059.0±839.6gvs.2250.9±726.6g,P=0.002)in  brain injury group were significantly lower;for 28 to 30,30 and 32 weeks at delivery, the risk of neonatal brain injury was respectively 6.6 times and 2.1 times more than 37 weeksat delivery.For neonatal birth weight less than 1500 g the risk of brain injury was 3.9 times more than the 2000 g. Complexity  monochorionic twins in brain injury group were significantly more(13.1% vs. 13/287,4.5%,P=0.000). The risk of neonatal brain injury of complexity monochorionic twins was 3.0 times as that of the singletons. Binary logistic regression analysis showed that the independent risk factors for neonatal brain injury were delivery gestational age(OR=0.891,95%CI:0.842~0.943)and complexity  monochorionic twins(OR=2.180,95%CI:1.108~4.288).Conclusions    Women with smaller delivery gestational age have higher risk for neonatal  brain injury. Complexity  monochorionic twins is another independent risk factor.

    Retrospective study of chemoradiotherapy compared with radiothrepy alone for cervical cancer.
    DU Jun-yao,ZHANG Xin,LI Lian-kun,WANG Chun-yan,WANG Xiao-bin,YU Ming-xin.
    2015, 31(3): 256-260.  DOI: 10.7504/fk2015020119
    Abstract ( )  

    Abstract: Objective To compare the treatment effects and toxicities after concomitant chemoradiotherapy(CRT) and radiothrepy(RT) alone for advanced cervical cancer.Methods A total of 264 patients with stages ⅡB~Ⅲ from Liaoning Cancer Hospital between Mar. 2007 to Oct. 2008 were analyzed retrospectively,132 in the CRT and 132 in the RT.

    The important role of multidisciplinary team in treatment of recurrent and drug-resistant gynecological malignant tumor.
    LI Xiu-qin.
    2015, 31(3): 267-270.  DOI: 10.7504/fk2015020122
    Abstract ( )  

    Abstract:For the patients with recurrent gynecological malignant tumor, especially those combined with drug-resistantce, according to the very complicated situation of each patient, we need to organize the specialized experts to discuss, study and formulate individualized treatment, making sure the patients can have the most advanced technology and/or treatment by the best path for reasonable treatment, to maximize the clinical curative effect. This fully embodies the biological - psychological - social treatment concept of being.people-oriented and the patient being the main body in modern medicine.