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    02 August 2014, Volume 30 Issue 8 Previous Issue    Next Issue

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    Nutritional intervention for gestational idiopathic diseases in China.
    ZHANG Jing, LIU Xing-hui.
    2014, 30(8): 577-581.  DOI: 10.7504/fk2014070101
    Abstract ( )   PDF (806KB) ( )  

    Abstract:Some pregnancy idiopathic diseases are found to be associated with pregnancy nutrition.Improving the nutritional status during pregnancy can control the occurrence and development of these pregnancy idiopathic diseases. This study mainly introduced the nutritional intervention of gestational hypertension disease, gestational diabetes, and gestational anemia. Studies on the nutrition intervention of intrahepatic cholestasis during pregnancy and hyperemesis gravidarum are absent.

    Importance of intervening the nutritional problems during pregnancy in based on evidences of developmental origins of health and disease (DOHaD).
    LI Ting,DUAN Tao.
    2014, 30(8): 582-585.  DOI: 10.7504/fk2014070102
    Abstract ( )   PDF (1011KB) ( )  

    Abstract: Pregnancy women may facing various nutritional problems during pregnancy including excess or insufficient energy intake, imbalance of macronutrients, deficiency of micronutrient . Based on evidences of developmental origins of health and disease (DOHaD), the fetal hypothalamic - pituitary - adrenaline-axis response, oxidative stress and epigenetic mechanisms can be permanently changed by these nutritional problems. The susceptibility to chronic non-communicable disease in adulthood is changed. Obstetricians should intervene the nutritional problems based on uptodate evidences to improve the health of the whole population.

    Prevention for hypertensive disorders in pregnancy with diet and nutrition interference.
    GOU Wen-li, ZONG Lu, FU Jing.
    2014, 30(8): 586-588.  DOI: 10.7504/fk2014070103
    Abstract ( )   PDF (793KB) ( )  

    Abstract: Hypertensive disorders in pregnancy was one of the most common complexity during pregnancy. It was well known that some risk factors such as obesity, malnutrition and deficiency of micro-nutrients. It was important to keep correct pregnant nutrition for maternal health and normal fetal development. Recently, with rapid economical progress, there were two phenomena existed in Chinese pregnant women: one was over-nutrition; the other was deficiency of micronutrient. Incidence of hypertensive disorders in pregnancy increased accordingly. Aiming on this situation, referring to relative researches, the writers made this review for the relationship between diet and nutrition interference with hypertensive disorders in pregnancy.

    The preventive role of trace elements in hypertensive disorders in pregnancy.
    MA Yu-yan, SANG Hong-ai.
    2014, 30(8): 589-592.  DOI: 10.7504/fk2014070104
    Abstract ( )   PDF (805KB) ( )  

    Abstract: Hypertensive disorders of pregnancy (HDP), defined as the edema, hypertension and proteinuria appeared after 20 week of pregnancy, is a pregnancy idiopathic complications that accounts for significant maternal and fetal morbidity and mortality. Although the potential pathogenesis is not fully understood, the imbalance and insufficiency of micronutrient element is regarded as important in the occurrence and development of hypertensive disorders in pregnancy. This article reviewed the relations between trace elements and hypertensive disorders in pregnancy.

    Folic acid and vitamins supplementation for the prevention of hypertensive disorders in pregnancy.
    GUO Fang, LI Xiao-tian.
    2014, 30(8): 592-596.  DOI: 10.7504/fk2014070105
    Abstract ( )   PDF (828KB) ( )  

    Abstract: Hypertensive disorders in pregnancy are composed of gestational hypertension, preeclampsia, eclampsia,and so on. The pathogenesis of preeclampsia is still not fully clarified;therefore, how to prevent the onset of preeclampsia is particularly important. Prevention includes medication, diet and lifestyle changes. Effect of calcium supplementation on prevention of preeclampsia is favorable and at present a variety of diet therapy including folic acid and vitamins(vitamin D, vitamin C & vitamin E) supplementation has been studied for the prevention of preeclampsia-eclampsia, but the effectiveness and safety of these methods is controversial.

    Nutritional management of preeclampsia.
    LI Li,ZHOU Li-juan.
    2014, 30(8): 596-599.  DOI: 10.7504/fk2014070106
    Abstract ( )   PDF (814KB) ( )  

    Abstract: The preeclampsia is a pregnancy-specific systemic disease. The cause of preeclampsia is unknown. We are concerned pregnancy nutrition in reducing the pathogenesis of preeclampsia. Control of risk factors for early prevention of eclampsia is helpful. Early nutritional supplements can improve maternal and fetal pregnancy outcomes.We should ensure that all pregnant women during pregnancy reasonable and adequate nutrient intake. The prevention of the occurrence of preeclampsia has important clinical implications.We need further research to provide more evidence about the role of nutritional supplements during pregnancy in the prevention of preeclampsia.

    Life style intervention for the prevention of gestational diabetes.
    WANG Shuang,YANG Hui-xia.
    2014, 30(8): 599-601.  DOI: 10.7504/fk2014070107
    Abstract ( )   PDF (797KB) ( )  

    Abstract: It has been confirmed that gestational diabetes increases adverse maternal and fetal outcomes, and the prevalence of GDM is increasing. More and more studies are focusing on life style intervention to prevent GDM. In order to provide some better advice about reducing the prevalence of GDM, the mechanism and effects of both physical activity and dietary intervention are summarized.

    Reasonable pregnancy nutrition on the mode of delivery.
    LI Jie,DU Juan.
    2014, 30(8): 601-602.  DOI: 10.7504/fk2014070108
    Abstract ( )   PDF (782KB) ( )  

    Abstract: With the improvement of people's living standards and family over concern for pregnant women, pregnancy obesity is becoming more serious. Pre-pregnancy BMI and gestational weight gain has become important factors of many adverse pregnancy outcomes, its influence on the mode of delivery has also gain more and more attention. Reasonable nutrition interventions is of great significance for reducing weight gain during pregnancy, controlling birth weight, reducing the cesarean section rate, thereby improving pregnancy outcomes.

    Distribution characteristics of deep infiltrating endometriosis and evaluation of accuracy of laparoscopic diagnosis.
    CHEN Shu-qin, FAN Li, JIN Wen-yan, ZHANG Huan-xiao, YAO Shu-zhong.
    2014, 30(8): 603-607.  DOI: 10.7504/fk2014070109
    Abstract ( )  

    Abstract: Objective To determine the characteristics of anatomical distribution of pelvic deep infiltrating endometriosis (DIE), and the correlation between visual and histologic findings of DIE at laparoscopy. Methods 79 patients with DIE underwent radical resection of endometriosis by laparoscopy. Various focus were resected in laparoscopic diagnose during the procedure and sent to pathological examinations. After pathological diagnosis were confirmed, the positive predictive value (PPV), negative predictive value(NPV), sensitivity(SEN)and specificity(SPE) for different endometriosis lesions diagnosed by laparoscopy were calculated. Results In the 274 focal lesions obtained by laparoscopy, DIE lesions tended to locate in posterior part of the pelvis were 242 (88.32%), and more in the left side (27.73%, 76/274) than right side (24.45%, 67/274). The most focus was uterosacral ligaments DIE (39.42%), rectum DIE (16.06%), rectovaginal septum DIE (12.04%) and posterior fornix DIE (9.12%) was in descending order. The coincidence rate of laparoscopic diagnosis for single DIE lesion was 92.7%, including intestinal wall lesion (100%), posterior fornix lesion (100%), rectovaginal septum lesion (96.97%), left and right uterosacral ligament lesion (83.64% and 90.56%), left and right ureter lesion (83.33% and 66.67%). PPV, SEN, NPV and SPE for diagnosis of DIE confirmed by laparoscope were 98.83%, 92.70%, 45.95% and 85%, respectively. Conclusion According to the pathology, the positive rate of DIE diagnosed by laparoscope is high.

    Laparoscopy versus laparotomy for endometrial cancer:system review.
    XIAO Chang-ji, ZHAO Jing, GUO Peng, XIANG Yang.
    2014, 30(8): 608-614.  DOI: 10.7504/fk2014070110
    Abstract ( )  

    Abstract: Objective To evaluate the clinical efficacy and safety of laparoscopy versus laparotomy for treatment of endometrial cancer.Methods The databases such as Cochrane Library,PubMed,EMbase,Ovid,CBM,WanFang Data,VIP Information and CNKI were searched to collect the randomized control trials (RCTs) between January 1990 and September 2013. The software of meta-analysis was RevMan 5.1. Results A total 13 RCTs include 7640 patients.There was no significant difference between laparoscopic and laparotomic approaches to endometrial cancer in 3-5 years overall survival, recurrence at 3-5 years follow-up, and the number of pelvic node yield. The bene?ts of laparoscopic surgery versus laparotomy were lesser amount of intraoperative bleeding (P= 0.0001), shorter length of hospital stay (P<0.00001), lower rates of total complications (P<0.00001) and postoperative complications (P<0.00001). Disadvantages were higher rates of intraoperative complications (P=0.03) and longer duration of surgical procedures (P= 0.004). Conclusion Compared with laparotomy, laparoscopic surgery seems to be beneficial in women with endometrial cancer, in particular as total complications and length of hospital stay.

    The effect of different doses of HCG on ICSI outcomes: according to serum E2 level on HCG day.
    WANG Guang-yan, NIU Zhi-hong, SUN Yi-juan, FENG Yun.
    2014, 30(8): 615-618.  DOI: 10.7504/fk2014070111
    Abstract ( )  

    Abstract: Objective To discuss the effect of different HCG doses according to serum E2 level on HCG day for triggering final oocyte maturation on ICSI outcomes. Methods This was a prospective study including 117 couples with an indication for ICSI between Jan. 2012 and Dec. 2012 at Reproductive Center of Ruijin Hospital. The dose of HCG for final oocyte maturation was used according to serum E2 level on HCG day as follows: if serum E2 concentration was ≤16 515 pmol/L, the dose of HCG was 7000 IU, serum E2 concentration ranged from 16 516 pmol/L to 23 854 pmol/L, the dose of HCG was 5000 IU, serum E2 concentration was ≥23 855 pmol/L, the dose of HCG was 3000 IU. The outcomes of three groups were compared. Results There were no significant differences among three groups on MⅡ rate and fertilization rate. The cleavage rate of 7000 IU group was significantly lower than 5000 IU group (96.43% vs. 99.62%). But the viability embryo rate of 7000 IU group was significantly higher than both 3000 IU group and 5000 IU group (65.43 vs. 55.69% and 57.74%, respectively). There was one moderate OHSS patient in 5000 IU group. There were no significant differences among three groups on mean number of embryo transfer, clinical pregnancy rate and implantation rate in fresh embryo-transfer cycles. Conclusion Using different doses of HCG according to serum E2 level on HCG day to trigger final oocyte maturation does not affect oocyte maturation and pregnancy rate. The principle that patient with high E2 concentration was given lower HCG dose and patient with low E2 concentration was given higher HCG dose was available.

    One tube method for chromosome preparation.
    LIU Tian-Sheng*, ZHENG Qian*, ZHENG Chen-Guang*, WEI Bo*, DU Juan*, ZHOU Yuan-yuan*, OU Shan*, FEI Dong-Mei*, HUANG Hong-qian*, CHEN Li-Li, QIU Xiao-Xia*.
    2014, 30(8): 619-622.  DOI: 10.7504/fk2014070112
    Abstract ( )  

    Abstract: Objective To assess a simple, economic and safe method of chromosome preparation in order to avoid samples mix-up and reduce the cost. Methods One thousand cases of blood samples and one thousand cases of tissue samples including amniotic fluid, chorionic villus and product of conception were taken in Guangxi Maternal and Child Health Care Hospital. All the samples were cultured and harvested by both of traditional and One Tube methods. Results Both methods were showed similar success rates and obtained satisfactory chromosome metaphases. In comparison of the traditional method, the One Tube method results showed that there were not samples mix-up and the average harvesting times were reduced by 1.5 minute for each blood sample and 12 minutes for each tissue sample. The average costs were reduced for each sample, blood 11.1 yuan and tissue 74.4 yuan. There was no incident of sample mix-up and no record of staff injury during the procedure. Conclusion One Tube method is a simple, safe, effective, less cost method of chromosome preparation.

    The diagnosis and treatment for rupture and bleeding of uterine and parauterine vein during pregnancy:analysis of six cases.
    SHI Chun-juan,WANG Le-jian, CAI Yan-e,ZHOU Jian-yu,LI Jin.
    2014, 30(8): 623-625.  DOI: 10.7504/fk2014070113
    Abstract ( )  

    Abstract: Objective To discuss the diagnosis and treatment for rupture and bleeding of uterine and parauterine vein during pregnancy and the prognosis of the pregnant women and fetus. Methods To retrospectively analyze the diagnosis and treatment course for the six cases of uterine and parauterine vein rupture and bleeding during pregnancy received between January, 2001 and August, 2012 in Taizhou Central Hospital. Results All of the six cases of pregnant women went to see a doctor for the acute abdominal pain symptoms with no obvious incentive, ultrasonography exam hinted the seroperitoneum, of which three cases were observed the hematoma ; non-coagulate bleed were drew by abdominocentesis and exploratory laparotomy were performed for the all cases; for one case who was mid-pregnancy with single fetus, seaming and hemostasis by tamping gelatin sponge was performed, and conservative therapy was conducted until the fetus was delivered for mature , the fetus by caesarean section is survived; four cases were late pregnancy with single fetus and were conducted caesarean section and the fetuses were all survived; the last case middle twin pregnancy was conducted caesarean section and the fetal death occurred. Conclusions Ultrasonic examination suggested that seroperitoneum occurred, the other pathogenesis was excluded and the non-coagulation fluid drew with abdominocentesis, the uterine and parauterine vein bleeding during in the duration of pregnancy can be diagnosed before operation so as immediate treatment can be performed to enhance the survival rate of the perinatal infant.

    Bone morphogenetic protein-2 on the invasion of HO8910 ovarian cancer cells.
    MA Ying,LENG Hong-rui, ZHANG Shu-lan.
    2014, 30(8): 626-630.  DOI: 10.7504/fk2014070114
    Abstract ( )  

    Abstract: Objective To verify the influence of bone morphogenetic protein-2 (BMP-2) on the invasion capacity of human ovarian serous cystadenoma cell HO8910, and to determine the possible mechanism.Methods Cell adhesion experiment, cross-river experiment and matrigel-transwell assay were performed to observe the influence of BMP-2 on the invasion ability of HO8910 cells. The changes of MMP-2 and TIMP-2 in HO8910 cells following BMP-2 intervention were also detected in Sheng Jing Hospital of China Medical University between 2008 and 2009.

    Traditional Chinese medicine treatment for intrauterine devices users with abnormal uterine bleeding.
    XU Li-qing*,ZENG Li-qin*,LAI Ying-hua*,ZENG Xian-qin.
    2014, 30(8): 631-633.  DOI: 10.7504/fk2014070115
    Abstract ( )  

    Abstract: Objective To observe the efficacy of modified Jiawei Shixiaosan in treating abnormal uterine bleeding according to the symptoms after using intrauterine devices(IUD). Methods A total of 90 cases of abnormal uterine bleeding after using IUD were collected in the Family Planning Station of Jiaoling between Jan. 2011 and Mar. 2013.The subjects were randomly divided into group A (the observation group )and group B(the control group).Group A was treated by modified Jiawei Shixiaosan according to the symptoms,group B was treated only by Jiawei Shixiaosan.Results Before the treatment,menstrual blood volume was (124.32±22.73) mL in group A and (126.49±23.76) mL in group B,the menstrual duration was (12.32±3.24) d in group A and (11.84±3.10) d in group B,the hemoglobin content was (113.31±11.49) g/L in group A and (113.93±7.89) g/L in group B.After the treatment,the menstrual blood volume was (70.38±13.73) mL in group A and (79.92±20.34) mL in group B,the menstrual duration was (6.44±1.22) d in group A and (7.08±2.11) d in group B,the hemoglobin content was (133.91±12.96) g/L in group A and (127.62±11.34) g/L in group B.Both groups had statistical difference in menstrual blood volume,menstrual duration and hemoglobin content before and after treatment (P<0.001).After treatment, thirty-four cases (75.5%) were cured in group A and twenty-five cases (55.5%) were cured in group B .In group A,the menstrual volume was lower,the cure rates was higher and the amount of hemoglobin in the blood was more than that in group B after the treatment.There was statistical difference between group A and group B(P<0.05). Conclusion The modified Jiawei Shixiaosan has better efficacy for IUD users with abnormal uterine bleeding which is worth being further study and apply.

    The preliminary application of bionic electrical stimulation therapy in intrauterine insemination.
    HE Qian-dong, SU Yuan-yuan, TANG Yan, HAN Yan-hua, CHEN Yan, LIN Feng-lian.
    2014, 30(8): 634-636.  DOI: 10.7504/fk2014070116
    Abstract ( )  

    Abstract: Objective To investigate the effect of bionic electrical stimulation therapy in improving the pregnancy outcome of intrauterine insemination (IUI). Methods 96 patients (146 IUI cycles) with both fallopian tube unobstructed between March 2012 and May 2013 were recruited in this study. They were divided into two groups according to whether the bionic electrical stimulation therapy was used during the IUI cycle. Results A total of 34 patients with 42 IUI cycles and 62 patients with 104 cycles were included into the study group and the control group,respectively. The pregnancy rate per cycle of the study group was significantly higher than that of the control group (28.6% versus 10.6%, P<0.05). In addition, both the mean age and the duration of infertility were higher in the study group when compared with the control group. Conclusion Bionic electrical stimulation therapy may be effective on improving the pregnancy rate of IUI. Further studies are needed in this area to investigate its effectiveness.