Abstract:

Abstract: Myasthenia gravis is an autoimmune disease of the neuromuscular junction characterized by skeletal muscle weakness. Disease exacerbations are more likely to occur in the first trimester or puerperium. A number of medications commonly used in obstetric practice can exacerbate the disease. The effect of myasthenia on pregnancy varies substantially from woman to woman and also from pregnancy to pregnancy in the same woman. Mainstay treatments involve acetylcholine esterase inhibitors, corticosteroids and other immunosuppressants, and adequate rest. Newborns may suffer, usually transient, which is due to transplacental antibody exposure in utero.

Key words: myasthenia gravis, pregnancy；acetylcholine esterase inhibitors

摘要：

重症肌无力是以骨骼肌收缩无力为特征的神经肌肉连接的自身免疫性疾病。疾病加重常常发生在早孕期和产后，一些产科常用药物可加重病情。重症肌无力对妊娠的影响在不同孕妇和同一孕妇的不同孕次之间差异很大。主要的治疗药物包括乙酰胆碱酯酶抑制剂、皮质激素以及一些免疫抑制剂，并保证充分休息。新生儿可以受累，但常常是暂时性的，常常是由于在宫内暴露于通过胎盘的抗体所致。

关键词: 重症肌无力, 妊娠, 乙酰胆碱酯酶抑制剂