Abstract:

Safety of assisted reproductive technology（ART）especially its effect on the general and mental health of ART offspring has been one of the focuses in recent years.Most studies have shown that the health state of children born from ART treatment is similar to that of naturally conceived children，suggesting ART is a relatively safe technology.There is an urgent need for long-term follow-up studies of IVF-conceived children，as it is too difficult to determine whether the observed associations demonstrated are related to the genetic origin of the children，or are related to the infertility per se，the IVF treatment per se，or the adverse obstetric outcomes associated with IVF treatment.

Key words: assisted reproductive technology, in vitro fertilization, health of offspring, mental health

摘要：

辅助生殖技术（ART）的安全性，尤其是对子代身心健康的影响，是近年来生殖医学研究的重点。多数研究表明，ART子代和自然妊娠子代的健康状况相似，辅助生殖技术是相对安全的；然而当前研究多集中于ART子代出生后早期的随访，尚无权威证据揭示其对子代成年后的远期影响，也无法明确已有的研究结论是否与遗传起源、不孕背景、体外受精（IVF）技术本身（如超促排卵用药、体外操作与培养等）和IVF相关的不良围产结局等有关。

关键词: 辅助生殖技术, 体外受精, 子代健康, 心理健康