Abstract:

Abstract： Objective To study the changes of high density lipoprotein(HDL) levels in patients with early onset severe preeclampsia and the clinical significance.Methods Forty-five cases of pregnant women with early onset severe preeclampsia were investigated,and 50 cases of normal pregnant women were randomly selected for normal control group.Serum HDL,apo-A1 and ACA-IgG,ACA-IgM tilters were measured in all cases.Results The positive rates of ACA in the early onset severe preeclampsia group was significantly higher than those in the control.Level of high density lipoprotein in early onset severe preeclampsia was higher than that of control group,but the level of ApoA1 was significantly lower in early onset severe preeclampsia group(P＜0.05).Levels of HDL and the ACA tilters had no correlations.Conclusion HDL may play an important pathological role in early onset severe preeclampsia.

Key words: early onset severe preeclampsia；high density lipoprotein, ACA

摘要：

目的 探讨早发型重度子痫前期患者血清中高密度脂蛋白（HDL）水平的变化及其在发病中的临床意义。方法 选择2011-11-01至2013-10-01于青岛市市立医院产科住院的45例早发型重度子痫前期患者为早发型重度子痫前期组，同期50例正常健康孕妇作为正常妊娠组。检测两组孕妇血清中HDL、载脂蛋白A1含量及抗心磷脂抗体(ACA)IgG、IgM滴度。结果 早发型重度子痫前期组患者血清中HDL含量和ACA阳性率均高于正常妊娠组，而载脂蛋白A1含量较正常妊娠组降低，两组差异有统计学意义（P＜0.05）；HDL含量与ACA滴度两组之间无明显相关性。结论 高密度脂蛋白可能与早发型重度子痫前期发病有关。

关键词: 早发型重度子痫前期, 高密度脂蛋白, 抗心磷脂抗体