Abstract:

Abstract： Objective To explore whether the PEA regimen can be used as the first-line chemotherapy drug for gestational trophoblastic neoplasms.Methods Retrospectively analyze 62 cases of gestational trophoblastic neoplasms from July 2004 to May 2013 in our hospital. Compare the treatment efficacy and side effects of these two regimens.Results   The effective rate of PEA regimen for the treatment of gestational trophoblastic neoplasms was 93.33%,higher than that of 5-Fu+KSM regimen,but it has no significant difference (P>0.05). In the aspect of the side effects, III～IV leukopenia, oral cavity ulcer and diarrhea of PEA group were less than those of 5-Fu + KSM group,being of  significant difference (P<0.05). In the aspect of nausea , vomiting and liver function damage, the occurrence rate  in PEA group was lower than that in 5-Fu + KSM group,but it was of no significant difference (P>0.05).Conclusion    Two regimens have the same effect, but PEA regimen has fewer side effects, shorter duration of average hospital stay and less treatment cost,which can be used as first-line chemotherapy drug for gestational trophoblastic neoplasms.

Key words: gestational trophoblastic neoplasms, DDP;VP16;KSM;5-Fu

摘要：

目的 探讨PEA方案是否可以作为妊娠滋养细胞肿瘤联合化疗一线选择。方法 回顾性分析中国医科大学附属盛京医院2004年7月至2013年5月62例妊娠滋养细胞肿瘤患者，评价顺铂+足叶乙甙+更生霉素（PEA方案,30例）与氟尿嘧啶+更生霉素（5-Fu+KSM，32例）方案的疗效和毒副反应。结果 PEA方案治疗妊娠滋养细胞肿瘤完全缓解率为93.33%，高于5-Fu+KSM方案组（90.63%）（P>0.05）。副反应PEA组Ⅲ～Ⅳ度粒细胞减少、口腔溃疡和腹泻情况明显少于5-Fu+KSM组，差异有统计学意义（P<0.05）。PEA组恶心呕吐和肝功能损伤的发生率及严重程度均低于5-Fu+KSM组（P>0.05）。结论 两方案治疗妊娠滋养细胞肿瘤疗效相当，PEA方案副反应小、疗程短、费用少，可以作为妊娠滋养细胞肿瘤联合化疗一线选择之一。

关键词: 妊娠滋养细胞肿瘤, 顺铂, 足叶乙甙, 更生霉素, 氟尿嘧啶