Abstract: Premature ovarian insufficiency（POI）is a clinical syndrome defined by loss of ovarian activity before the age of 40 years.Its terminology has experienced premature ovarian failure，primary ovarian insufficiency，and so on.Premature ovarian failure（POF）often refers to the final stage of ovarian dysfunction，and it is a devastating diagnosis for women，especially for those who have not yet completed childbirth.Premature ovarian insufficiency（POI）may better reflect the decline of ovarian function with gradual fluctuation.The current diagnosis should be confirmed with age＜40，oligo/amenorrhea for at least 4 months（including primary and secondary amenorrhea）and an elevated FSH level ＞25U/L on two occasions（＞4 weeks apart）.The advance of FSH threshold can help to identify and treat POI patients early.This may make the final fertility possible for those patients.This article focuses on the terminology changes of POI，hoping to provide better clinical understanding of“POI”.

Key words: premature ovarian insufficiency, premature ovarian failure, diagnosis

摘要： 早发性卵巢功能不全（premature ovarian insufficiency，POI）是指40岁之前妇女卵巢功能减退导致的临床综合征，其称谓经历了卵巢早衰、原发性卵巢功能不全等。卵巢早衰往往反映的是卵巢功能减退的终末阶段，其诊断令患者难以接受，尤其是那些还没有完成生育的女性。POI则能更好地反映卵巢功能逐渐波动下降的过程。POI目前的诊断标准为年龄＜40岁，月经稀发或停经至少4个月以上（包括原发和继发性闭经），至少2次血清基础卵泡刺激素（FSH）检测均＞25U/L（间隔4周以上）。FSH诊断阈值的关口前移可以使POI患者更早被发现和治疗，并可能使患者获得最后的生育机会。文章着重阐述了POI诊断名称的历史变迁，以便于临床更好地了解POI诊断名称的含义。

关键词: 早发性卵巢功能不全, 卵巢早衰, 诊断