Abstract: Recurrent pregnancy loss（RPL）is a common disease which affects many women of reproductive age. Embryonic chromosomal abnormality is one of main causes of RPL. In recent years，with the development of preimplantation genetic testing （PGT），which can be used to avoid miscarriage caused by embryonic aneuploidy，clinical application of PGT has been increasing in patients with RPL.This paper will review the advances of PGT technology during the past 30 years since its invention with regard to testing technique，biopsy technique and its clinical application in RPL.

Key words: recurrent pregnancy loss, preimplantation genetic testing

摘要： 反复妊娠丢失（RPL）是困扰育龄期女性的常见疾病，胚胎染色体异常是导致RPL的最常见因素。近年来，随着植入前遗传学检测（PGT）技术的发展，可以更有效地避免因胚胎非整倍体导致的流产，PGT 在RPL患者中的临床应用日益广泛。文章回顾PGT技术自问世以来30年间的发展过程，从检测技术、活检技术、临床应用等方面，包括其在RPL中的应用进展做一阐述。

关键词: 反复妊娠丢失, 植入前遗传学检测