关键词: 孕激素, 子宫颈机能不全, 早产, 治疗

Abstract: Progesterone is a steroid hormone which plays an essential role in the menstrual cycle and implantation and at each step of human pregnancy. Since the synthesis of progesterone drugs，progesterone therapy has been used to prevent and treat implantation failure，miscarriage and premature birth，and is also used in cervical insufficiency. With the development of evidence-based medicine，although the evidence about the actual roles of progesterone have increased greatly， many controversies still remain. The purpose of this review is to summarize knowledge about the use of progesterone in cervical insufficiency.

Key words: progesterone, cervical insufficiency, preterm birth, therapy