中国实用妇科与产科杂志

中国实用妇科与产科杂志 ›› 2022, Vol. 38 ›› Issue (11): 1079-1083.DOI: 10.19538/j.fk2022110105

• 专题笔谈 • 上一篇    下一篇

妊娠滋养细胞肿瘤生育力保护研究现状

  

  1. 中国医学科学院 北京协和医学院 北京协和医院妇产科，北京 100730 
  • 出版日期:2022-11-02 发布日期:2022-11-02
  • 通讯作者: 向阳
  • 基金资助:
    国家自然科学基金（81971475）

Research progress of fertility protection in gestational trophoblastic tumors.

  1. Department of Obstetrics and Gynecology，National Clinical Research Center for Obstetric & Gynecologic Diseases，Peking Union Medical College Hospital，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100730，China
  • Online:2022-11-02 Published:2022-11-02

摘要： 妊娠滋养细胞肿瘤（gestational trophoblastic neoplasms，GTN）包括侵蚀性葡萄胎、绒毛膜癌、胎盘部位滋养细胞肿瘤和上皮样滋养细胞肿瘤。GTN多发生于育龄妇女，因此，治疗的同时保留患者的生育力尤为重要。文章阐述了保留生育力治疗GTN的方法，如全身静脉化疗或动脉插管化疗、动脉栓塞治疗、保守性手术、免疫治疗等，并总结保留生育力治疗后的妊娠结局等相关问题。

关键词: 妊娠滋养细胞肿瘤, 保留生育力治疗, 化疗, 手术, 免疫治疗

Abstract: Gestational trophoblastic neoplasms（GTNs） include invasive hydatidiform mole，choriocarcinoma，placental site trophoblastic tumors and epithelioid trophoblastic tumors. GTN mostly occurs in women of child-bearing age，so it is particularly important to preserve the fertility of patients. This paper expounded the methods of fertility-sparing treatments for GTN，such as systemic intravenous chemotherapy or arterial intubation chemotherapy，arterial embolization，conservative surgery，and immunotherapy. The pregnancy outcomes after fertility-preserving treatment were summarized.

Key words: gestational trophoblastic neoplasms, fertility sparing treatment, chemotherapy, surgery, immunotherapy

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