高危妊娠滋养细胞肿瘤的治疗原则是联合化疗为主，手术、放疗、靶向和免疫等综合治疗为辅，总的来讲预后良好，但仍有患者因肿瘤复发耐药而死亡。文章对近年来高危妊娠滋养细胞肿瘤的治疗进展做一概述，为临床治疗提供参考。

The treatment principle of high-risk gestational trophoblastic neoplasia is mainly the combined chemotherapy，supplemented by comprehensive treatment such as surgery，radiotherapy，targeted and immune therapy. In general，the prognosis is good，but there are still patients who die due to tumor recurrence and drug resistance. This article summarizes the recent progress in the treatment of high-risk gestational trophoblastic neoplasia and provides a reference for clinical treatment.