中国实用妇科与产科杂志

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子宫肌瘤药物治疗

杨欣   

  1. 作者单位:北京大学人民医院妇产科,北京100044
  • 出版日期:2012-12-02 发布日期:2012-11-19

  • Online:2012-12-02 Published:2012-11-19

摘要:

目前尚无治疗子宫肌瘤的有效药物。促性腺激素释放激素激动剂(GnRHa)能改善术前贫血症状,但费用高并可导致低雌激素状态。芳香化酶抑制剂和选择性雌激素受体调节剂(SERM)在绝经后有症状的子宫肌瘤治疗中有效。使用米非司酮治疗,闭经率高,副反应小。左炔诺孕酮宫内节育系统(LNGIUS)可治疗子宫肌瘤合并月经过多。

关键词: 子宫肌瘤, 促性腺激素释放激素激动剂, 米非司酮, 左炔诺孕酮宫内节育系统

Abstract:

There is no effective medical therapy to date. GnRHa are useful preoperatively. Aromatase inhibitors and SERM may be useful in postmenopausal woman with symptomatic myoma. Lowdose mifepristone is a relatively cheap drug with minimal sideeffects. The use of Levonorgestrelreleasing intrauterine system has been shown to reduce menstrual blood loss with idiopathic menorrhagia or menorrhagia due to leiomyomas.

  

Key words: uterine myoma, gonadotrophin-releasing hormone analogues, mifepristone, LNG-IUS

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