目前尚无治疗子宫肌瘤的有效药物。促性腺激素释放激素激动剂(GnRHa)能改善术前贫血症状，但费用高并可导致低雌激素状态。芳香化酶抑制剂和选择性雌激素受体调节剂(SERM)在绝经后有症状的子宫肌瘤治疗中有效。使用米非司酮治疗，闭经率高，副反应小。左炔诺孕酮宫内节育系统(LNGIUS)可治疗子宫肌瘤合并月经过多。

There is no effective medical therapy to date. GnRHa are useful preoperatively. Aromatase inhibitors and SERM may be useful in postmenopausal woman with symptomatic myoma. Lowdose mifepristone is a relatively cheap drug with minimal sideeffects. The use of Levonorgestrelreleasing intrauterine system has been shown to reduce menstrual blood loss with idiopathic menorrhagia or menorrhagia due to leiomyomas.