中国实用妇科与产科杂志

中国实用妇科与产科杂志

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妊娠合并系统性红斑狼疮与不良妊娠结局

  

  1. 广州医科大学附属第三医院产科 广州重症孕产妇救治中心，广东 广州 510150
  • 出版日期:2020-05-02 发布日期:2020-05-11
  • 通讯作者: 贺芳
  • 基金资助:
    国家自然科学基金（81601349）

Pregnancy with systemic lupus erythematosus and adverse pregnancy outcome.

  1. Obstetric Department，Guangzhou Medical Centre for Critical Pregnant Women of the Third Affiliated Hospital of Guangzhou Medical University，Guangzhou 510150，China
  • Online:2020-05-02 Published:2020-05-11

摘要： 系统性红斑狼疮（SLE）是好发于育龄期女性的自身免疫性结缔组织病。系统性红斑狼疮患者发生不良妊娠结局的风险高达19.0%～70%。妊娠合并SLE常见的不良妊娠结局包括狼疮复燃、流产、早产、子痫前期、胎儿生长受限、新生儿狼疮等。当SLE同时伴有特异性抗体如抗磷脂抗体时，不良妊娠结局的发生风险上升28.4%；伴有Ro/La抗体时，胎儿、新生儿先天性心脏传导阻滞发生率为1%～2%。SLE缓解期在医生指导下计划妊娠、孕期严密监测、个体化及多学科管理是改善不良妊娠结局的关键。

关键词: 系统性红斑狼疮, 妊娠, 不良妊娠结局

Abstract: Systemic lupus erythematosus （SLE） is an autoimmune connective tissue disease that affects women at child-bearing ages.Adverse pregnancy outcome （APO） occurred in 19.0%-70% of pregnancies with SLE，including recurrent lupus，pregnancy loss，preterm delivery，preeclampsia，fetal growth restriction，neonatal lupus and so on.When the SLE is accompanied specific antibody，such as antiphospholipid antibody，the APO rate increases by 28.4%，and when the SLE is accompanied by anti-Ro /La antibody，the occurrence rate of fetal or neonatal heart block is 1%-2%.Planned pregnancies in stable stage of SLE，close monitoring and individualized multidisciplinary management during pregnancy are keys to improving APO.

Key words: systemic lupus erythematosus, pregnancy, adverse pregnancy outcome

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