Archive

06 June 2006, Volume 21 Issue 06 Previous Issue    Next Issue
---
论著


For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

论著

Select

Clinical and pathological features of children with IgA nephropathy. Mao Huaxiong,Yi Zhuwen,He Yiwei 2006, 21(06): 425-427 .  Abstract ( )   AbstractObjectiveTo investigate clinical and pathological features of children with IgA nephropathy (IgAN). MethodsTo characterize the clinical manifestations and pathological changes of 64 children with IgAN depending upon the course of disease and clinical type. ResultsIsolate hematuria and nephrotic syndrome of IgAN were major clinical types in 64 cases,accounting for 73% (47/64).Upon the course of disease,three pathological changes such as inflammation cells infiltration,renal tubule degeneration and renal interstitial fibrosis predominated,of whom renal interstitial fibrosis unbalancedly distributed between the group of less than or equal to one year and more than one year,which was closely related to unbalanced distribution of nephrotic syndrome IgAN,in which the three changes were more obvious than other clinical type of IgAN. ConclusionIn 64 children with IgAN,isolate hematuria and nephrotic syndrome are main clinical type of IgAN.Nephrotic syndrome IgAN or continuous proteinuria is the major cause leading to renal interstitial fibrosis.Early control of proteinuria would delay or decrease renal interstitial fibrosis.

Select

The application of multispiral CT angiography to the diagnosis of renovascular hypertension in children. Sun Shuzhen ，Wang Yi，Wang Ximing 2006, 21(06): 428-430 .  Abstract ( )   AbstractObjectiveTo discuss the clinical application of multispiral CT angiography (MSCTA) to the diagnosis of renovascular hypertension in children. MethodsSince 2002,8 cases of diagnosed renovascular hypertension underwent MSCTA.8 cases received colourcoded Doppler ultrasonography(DUS) and 6 cases received Xray angiography (XRA).The results were compared.The scanning paremeters were as follows:collimation 075 mm,pitch 1,tube voltage 90~120kV and tube current 120~150mAs.After scanning,multiplanar reconstruction(MPR)(coronal,sagittal,oblique),maximum intensity projection(MIP) and volume rendering(VR) were reconstructed. ResultsWe visualized 10 renal arterial stenosis ( left 6 and right 4,including 2 bilateral stenosis) in 8 cases by MSCTA.Among these renal arteries 8 had lesions in the origins and 2 in the middle.The length of stenosis was 02~10cm and the Grade 1 stenosis was one renal artery,Grade 2 six renal arteries,and grade 3 three renal arteries.MSCTA showed 6 kidneys dwindled with average length 71cm,which was 15cm less than normal kidneys.One case was accompanied by wallthickening and cavitary stenosis of abdominal aorta.The locations and extent of stenosis in 6 cases by XRA and by MSCTA were identical.We found renal arterial stenosis only in 5 of 8 cases and 6 dwindled kidneys by DUS. ConclusionMSCTA can not only reveal the extent and locations of renal arterial stenosis,but also show the walls and lumens of the renal arteries.As a noninvasive and valuable examination,MSCTA can replace invasive selected renal arteriography to some extent.

Select

Changes of growth factorinsulinlike growth factor axis in the children with congenital heart disease. Wei Dan,Lu Yuanfeng,Li Yanqing. 2006, 21(06): 431-432 .  Abstract ( )   AbstractObjectiveTo investigate the changes of growth hormoneinsulinlike growth factor(GHIGF) axis in the children with congenital heart disease (CHD). MethodsSerum growth hormone binding protein (GHBP) was determined in 50 children with CHD and 20 normal children from Jan.2004 to Oct.2004 by enzymelinked immunosorbent assay (ELISA); serum insulinlike growth factor1 (IGF1) and insulinlike growth factor binding protein3 (IGFBP3) were determined by immunoradiometric assay. ResultsThe levels of serum IGF1 and IGFBP3 decreased in the patients with CHD; they were significantly decreased in the cyanotic group and heart failure group.The level of serum GHBP was decreased in the cyanotic group and heart failure group. ConclusionCyanotic patients are the ones most severely affected.GHIGF axis is disordered in the patients with CHD.It is suggested that reduced growth hormone receptor status represents one of the molecular mechanisms of GH insensitivity in the CHD.

Select

Clinical analysis of 174 children with infectious endocarditis. Wang Xiuying,Liu Donghai,Xu Yi. 2006, 21(06): 433-435 .  Abstract ( )   AbstractObjectiveTo research into the clinical characteristics,therapeutic approach and in children with infectious endocarditis. MethodsClinical data of 174 children patients with IE treated in Xiangya Second Hospital of Central South University from 1980 to 2004 were reretrospectively analyzed. Results1.There are 99 patients resulting from congenital cardiovascular diseases,35 patients from rheumatic heart disease,35 patients from heart diseases without parenchymal,4 patients after operation of congenital cardiovascular diseases and 1 patient from hypertrophic cardiomyopathy (HCM).2.Clinical manifestations were: fever(86%)，hepatomegaly(425%)，splenomegaly(316%)，anaemia(374%)，erythrosedimentation faster(391%) and multiple organ embolism(178%)and 76 patients’ germiculture was positive,the rate being 4367%,and 55 patients resulted from staphylococci.3.The most concerned heart valve was diopathic mitral valve echocariogram witch,covering 483%.4.The most common complication of IE was intractable heart failure(252%),the second being nervous system complication(132%).5.Because the clinical manifestation of IE was not typical,the cases were often misdiagnosised as influenza,pneumonophthisis,acute rheumatic fever,glomerular nephritis and others.6.The cure rate of IE was 609%,among which,76 patients were cured simply by antibiotics (716%) and 30 patients were cured by antiinfection combining operation(283%);28 patients died.Cerebral embolism and intractable heart failure were common death causes in IE. ConclusionCongenital cardiovascular diseases is in the first place in the basic heart diseases,and rheumatic heart disease is decreasing gradually.Hemoculture and echocardiogram are helpful for the diagnosis of IE.The most important measure is antibiotics.The children patients should turn to surgical therapy if the medical curative effect isn t satisfactory.

Select

Investigation of plasma lipid value in 7~18 years old adolescents in Beijing area. Liu Ying,Mi Jie,Du Junbao. 2006, 21(06): 436-438 .  Abstract ( )   AbstractObjectiveThis study aimed to establish the latest normal value of plasma lipid in 7~18 years old children in Beijing via the investigation. MethodsA total of 971 healthy school students were chosen randomly,all coming from Beijing city and its counties.They were divided into eight groups according to their gender and age (7~9 years old boys and girls; ~12 years old boys and girls; ~15 years old boys and girls; ~18 years old boys and girls).Total cholesterol (TC),triglyceride (TG),high density lipoproteincholesterol (HDLC) and low density lipoproteincholesterol (LDLC) were detected by HITACHI 7060 automatic biochemical analyzer.The 75th and 90th percentiles of TC and LDLC levels were adopted as the borderline and high of hypercholesterolemia.The 90th percentile of TG was served as the cutoff of hypertriglyceridemia.And the 5th of HDLC acted as the lower limit to establish the new criteria of dyslipidemia in Beijing children. ResultsSerum lipid values in 971 school students took on a positive skew distribution.There was no statistical significance between males and females in 7 to 9 years old group of their TC,TG,HDLC and LDLC levels.In ~12 years old group,there was a difference between the two sexes in TG level.While in ~15 years old group,TC and LDLC levels in females were both higher than those of males.In ~18 years old group,TC and HDLC values were higher in females than in males. ConclusionNew criteria of plasma lipid values in children in Beijing are established by our investigation in 971 healthy school students.Age and sex have been analyzed.Borderline and high of TC and LDLC levels have been settled.Cutoff of hypertriglyceridemia and hypohigh density lipoprotein cholesterolemia have also been established.

Select

Correlation between Kawasaki disease and 4G/5G polymorphism of plasminogen activator inhibitor1 gene promoter. Yuan Xiongwei,Yang Jun,Liu Cong 2006, 21(06): 439-441 .  Abstract ( )   AbstractObjectiveTo investigate the genetic association of the PAI1 promoter 4G/5G polymorphism in juvenile Hans nationality patients with KD. MethodsFrom 2001 to 2003 4G/5G polymorphism of PAI1 gene promoter from 126 children with KD was determined by allele specific polymerase chain reaction(ASPCR),and 120 agematched normal children from the Han nationality were used as control.The plasma PAI1 activity was assayed by ELISA.All patients were performed Doppler echocardiography examination in order to differentiate coronary artery lesion(CAL). ResultsThe plasma PAI1 activity level in two KD groups were significantly higher than those in normal controls group(P<005);the plasma PAI1 activity level in the KD I group(with CAL) was significantly higher than those in the KD II group(without CAL)( P<001).PAI1 level in 4G homozygous genotype was significantly higher than 4G/5G heterozygous genotype and 5G homozygous genotype in two KD groups (P<005).The 4G/4G genotype frequency in KD I group was significantly higher than those in KD II group(P<005) and normal controls group(P<005).The 4G/4G homozygous genotype of PAI1 was significantly associated with CAL caused by KD(OR=280,95%confidence interval 125~629,P<005). ConclusionThe 4G/5G polymorphism of PAI1 gene promoter might be related to the coronary artery complication of KD and 4G/4G homozygous genotype might be regarded as a genetic marker of risk factor for CAL in KD.

Select

Study on prognosis of Kawasaki disease treated with intravenous gamma globulin(IVGG) after abatement of fever. Wang Cuihua. 2006, 21(06): 442-443 .  Abstract ( )   AbstractObjectiveTo study the dose of IVGG in treating Kawasaki disease(KD) at defervescence and the necessity. MethodsClinical data of 56 cases of Kawasaki disease without coronary artery lesion(CAL) but with abatement of fever in 10 days were retrospectively analyzed.They were divided into three groups according to IVGG dosage:group A (1g/kg IVGG n=11),group B (2g/kgIVGG n=26)and C(blank n=19).CAL was observed at 14~21days and 05 year. ResultsCompared with group A and B,the rate of CAL was significantly higher (P<001)in group C at 14 ~21days and 05 year,while no difference between group A and B at the two stages(P>005). ConclusionIn order to prevent CAL,KD children with confirmed diagnosis in 10 days should all be treated with IVGG whether with abatement of fever or not.The dose of 1g/kg IVGG would have satisfactory effects on KD children at defervescence.

Select

Complete atrioventricular block resulted from myocarditis in 17 children. Wang Jianyi,Chen Xiuyu,Huang Min 2006, 21(06): 444-445 .  Abstract ( )   AbstractObjectiveAnalyzing the clinical characteristics and the treatment in 17 children with complete atrioventricular block (CAVB) resulted from the infectious myocarditis. MethodsFrom Aug.1984 to Mar.2005,17 cases of CAVB resulted from the infectious myocarditis were reviewed. ResultsOf the 17 children reviewed,8 had AdamsStoke syndrome and 5 had heart failure;13 of them had cardiomegaly on chest xray.The echocardiography in 13 cases all showed left ventricular enlargement.The average ventricular rate on electrocardiogram was (528±104)/min.Six patients with the fulminant myocarditis were given the methylprednisolone and medication for protecting the damaged myocardium.Three patients were given emergence temporary pacing.The rest children were given the medicine for improving conduction.In this group,6 patients were cured,and 5 patients showed clinical improvement,but 5 patients still showed CAVB and 1 patient died. ConclusionCAVB associated with acute myocarditis may be lifethreatening;if the patients are diagnosed early enough and are given large doses of the adrenal cortical hormone in time and administered emergence temporary pacing,the prognosis will be much better.On the other hand,if atrioventricular block occurs on followup,bundle branch block appears and QRS widens with the nodal escape,the diease may progress to CAVB.

Select

The clinical significance of anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis. Kang Min,Wang Hongwei,Cheng Peixuan 2006, 21(06): 446-448 .  Abstract ( )   AbstractObjectiveTo investigate the clinical significance of antiCCP antibodies in juvenile idiopathic arthritis (JIA). MethodsFrom June 2002 to Aug.2004,enzymelinked immunosorbent assay(ELISA)was used for the detection of antiCCP antibody of 106 children (including 66 cases of JIA，11 other rheumatoid disease patients and 29 healthy children) to compare the positive rate of the groups. ResultsAntiCCP antibody was found in 11/66 (167%) JIA patients，including 4/7 patients with RFpositive polyarthritis,4/21 with RFnegative polyarthritis and 3/13 with oligoarthritis.None of the systemic onset and enthesitisrelated arthritis patients was positive for antiCCP antibody,Neither was the group of other rheuamatoid disease patients and 29 healthy children.There showed significant difference between JIA patients and control children(P<005),so did polyarthritis and oligoarthritis subtype compared with control children. ConclusionAntiCCP antibody cannot yet be considered as an important serological marker for the early diagnosis of JIA.AntiCCP antibody shows relatively higher positive rate in JIA patients of polyarthritis and oligoarthritis subtype,which indicates antiCCP antibodies may have an important role in JIA typing and prognosis of JIA.

Select

Prevalence of congenital heart diseases in patients with oral cleft palate in Guangdongprovince. Guo Yan，Yu Minghua，Liu Techang 2006, 21(06): 449-450 .  Abstract ( )   AbstractObjectiveTo explore the prevalence of congenital heart disease (CHD) in cleft patients. MethodsFrom Jan.2004 to May 2005,a colour Doppler echocardiogram was performed on 567 patients with oral cleft palate in Guangzhou Children's Hospital.The results were analysed with statistics. ResultsThirtyseven patients were found to have CHD in 567 patients (653%);6 cases of them occurred in group with cleft lip (521%),15 patients occurred in the group of cleft palate(1056%),and 16 patients occurred in the group of cleft lip and palate (554%).Atrial septal defects(ASD),patent ductus arteriosus(PDA) and ventricular septal defects(VSD) were the commonst malformation in the study. ConclusionThe prevalence of CHD in cleft patients is high.Color Doppler echocardiography is a useful and reliable tool in diagnosing CHD in patients with oral cleft palate of all kinds’ CHDS.

Select

The effect of early intervention in the enhancement of feeding function in children with cerebral palsy. Ye Wen,Yu Jian Min,Wu Wenlue. 2006, 21(06): 451-452 .  Abstract ( )   AbstractObjectiveTo study the effect of early intervention in the enhancement of feeding function in children with cerebral palsy. MethodsFrom Mar.2002 to Oct.2004,thirtyfour CP children accepted early feeding and mouse practice rehabilitation training,then were evaluated feeding function in six to twelve months.Fortytwo CP children in control group received evaluation before rehabilitation training.Compare the two groups' results. ResultsThe occurrance rate of observation group’ feeding problem was markedly lower than the control group( P<005). ConclusionEarly intervention can promote the improvement of feeding function of children with cerebral palsy.

Select

The effect of the UDPglucoronyl transferase 1A1 gene mutation and glucose6phosphate dehydrogenase deficiency on neonatal bilirubin level. Fu Wenping,Wang Weiya,Wang Heng. 2006, 21(06): 453-454 .  Abstract ( )   AbstractObjectiveTo investigate the roles of G71R mutation of the uridine 5 diphosphateglucuronyl transferase 1A1 gene and glucose6phosphate dehydrogenase to bilirubin levels during the first three days of life. MethodsEightyone umbilical cord blood samples had been collected for neonatal screening of G6PD activity and identification of G71R mutation by allelespecific oligonucleotide assay.We compared the bilirubin levels during the first three days after birth between different groups. ResultsAmong the G6PD deficient neonates,the bilirubin levels of the second and third day for G71R homozygous or heterozygous group were significantly higher than those of G71R widetype group.Among G6PD normal neonates,no significant differences were noted for the bilirubin levels during the first three days after birth between G71R homozygous or heterozygous group and G71R widetype group.Among G71R widetype neonates,no significant differences were noted for the bilirubin levels during the first three days after birth between G6PDdeficient group and G6PDnormal group. ConclusionG71R gene mutation combined with G6PDdeficiency aggravates the degree of neonatal jaundice.

Select

Analysis of 6 children with the preceding acute lymphoblastic leukemia and review of literature. Wen Jinquan,Zhang Qiuping,Wang Yaoping. 2006, 21(06): 455-456 .  Abstract ( )   AbstractObjectiveTo improve the diagnosis of preceding acute lymphoblastic leukemia (PreALL). MethodsClinical and laboratory characteristics were reviewed in 6 cases of PreALL admitted between 1997 and 2004. ResultsFour males and 2 females,aged from 2 to 8 years old,all the cases had fever,anemia and bleeding,four cases with hepatosplenomegaly,enlargement of lymphonode and pancytopenia,four cases with hypoplasia of bone marrow;more fat tissue and less hematopoietic tissue were found in the four cases of bone marrow biopsy;two cases with drydraw of bone marrow had proliferation of fibrotic tissue;two children pccurred pathologic hematopoiesis.All these patients transformed to ALL within one to nine months with or without steroids therapy.Three of the ALL were given VDLP and got complete relief. ConclusionSome patients diagnosed as aplastic anemia at first can transform to ALL,with good response to chemotherapy.Part of the children with preALL may show abnormal morphology in bone marrow.

Select

IFNγ enhance the ability of the inhibition of TRAIL to neuroblastoma cell line. Li Aimin,Zhang Ying,Yu Huiqin 2006, 21(06): 457-459 .  Abstract ( )   AbstractObjectiveTo explore the effect of TRAIL on neuroblastoma cell line and the influence of IFNγ on the antitumor effects of TRAIL. MethodsUse MTT and flow cytometric analysis to detect the antitumor effects of TRAIL and study the effects of IFNγ on TRAIL in inhibiting human neuroblastoma cells. ResultsThe rates of killing of TRAIL alone、IFNγ alone and the combination of TRAIL and IFNγ were (503±126)%、(533±206)%、(4122±709)%,IFNγ could enhance the killing rate of TRAIL to the SY5Y cells.FCM analysis suggested that IFNγ enhanced the killing rate of TRAIL to the SY5Y cells based on inhibiting apoptosis of SY5Y cells. ConclusionSHSY5Y cells are not sensitive to TRAIL.IFNγ can upregulate the apoptosis of SY5Y induced by TRAIL.