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Observation of gemfibrozil treating hyperlipidemia in nephrotic come of steroidresistance.
YAO Yong,YANG Jiyun,WANG Hongyan
2007, 22(01):
36-38 .
AbstractObjectiveIt was known that hyperlipidemia,as one complication of nephrotic syndrome,had renal toxicity.To observe the
effect and security of gemfibrozil treating hyperlipidemia in children with active steroidresistance nephrotic syndrome(SR
NS).MethodsEight children with SRNS were administered gemfibrozil (BWt<20kg,0.3/d; BWt>20kg,0.3 Bid) whit normal liver
function before lipidlowing treatment.The changes of plasma lipids (TC,TG) and lipoprotins (LDL,VLDL,HDL),albumin,serum
creatinine(SCr),aminotransferase(ALT) and drug sideeffects were observated for 4 weeks.ResultsWe found that there were
decreasing of plasma lipids and lipoproteins after 2 weeks of gemfibrozil treatment,especially TG(P<0.05).The decreasing of
TC,VLDL,LDL and raising of HDL had significant difference at 4th week.The average reducing rate of TG was 48.2%,TC was
31.8%.There were no significant difference between before and after lipidlowing treatment in renal and liver function.All
of our patients' renal and liver function was in normal range except that one boy who had renal insufficiency before
gemfibrozil treatment had little raising of Scr.There was no sideeffect found except another patient who had temporary
abdominal pain and nausea.ConclusionOur result showed that it is effective and safe to treat the steroidresistence
nephrotic hyperlipidemia in childhood with gemfibrozil for shortterm,especially for patients with raising TG,but we would
pay more attention to patients with renal insufficiency.
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