Studies on the relations between changes of insulin、growth hormone and cortisol in premature infants with intrauterine

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Studies on the relations between changes of insulin、growth hormone and cortisol in premature infants with intrauterine

growth retardation.YAO Mingzhu，LU Guoqiang，CHEN Hao，et al.

Department of Neonatology, Shanghai First Maternity and Infant Hospital, Shanghai 200040,China

Received:2006-06-10 Revised:2006-10-15 Online:2007-01-06 Published:2007-01-06

宫内发育迟缓早产儿胰岛素生长激素及皮质醇的变化和发病关系研究

姚明珠，陆国强，陈豪，印学蕾，吴莉，戴芸佳，郭佳林，丁效薇，胡勇，徐秋玲

上海市第一妇婴保健院儿科暨上海市早产儿医疗

Abstract

Abstract: AbstractObjectiveTo investingate the relations of insulin(Ins)、growth hormone (GH) and cortisol (Cor) with intrauterine growth retardation (IUGR).MethodsBlood samples were collected from mothers、umbilical cord and 7day infants in forty cases of premature infant with IUGR and fortyfive cases of appropriate for gestational age infant(AGA),and the concentrations of Ins、GH and Cor were measured by radioimmunoassay, and the results were analyzed and compared.ResultsThe serum Ins of umbilical cord and 7day infant in IUGR group were significantly lower than those in the control group (P<0.01). The maternal serum GH、Cor in IUGR group were significantly lower than those in the control group (P<0.05). There was no significant difference of serum Cor in umbilical cord and 7day infant between IUGR group and control group (P>0.05).ConclusionThe change of Ins、GH and Cor levels in maternal、umbilical and 7day infant serum may play an important role in the pathophysiological changes in IUGR of premature infants.

Key words: Growth hormone, Cortisol , Premature infant, Insulin

摘要： 摘要】目的探讨胰岛素(Ins)、生长激素(GH)、皮质醇(Cor)与早产儿宫内发育迟缓 (IUGR)的关系。方法采用放射免疫分析法检测40例IUGR早产儿和45例适于胎龄早产儿(对照组)母血、脐血和生后7日龄血清中的Ins、GH、Cor含量，并进行分析比较。结果Ins在IUGR组脐血、生后7日龄血清中的含量明显低于对照组(P<0.05)。GH、Cor在母血中含量明显低于对照组 (P<0.05)。而脐血、生后7日龄血清中Cor含量在IUGR高于对照组，但二组比较差异无显著性(P>0.05)。结论早产儿IUGR与Ins、GH、Cor等内分泌激素有关，它们通过调节代谢而影响胎儿宫内的生长发育，发挥着较重要的作用。

关键词: 宫内发育迟缓, 早产儿, 胰岛素, 生长激素, 皮质醇

growth retardation.YAO Mingzhu，LU Guoqiang，CHEN Hao. Studies on the relations between changes of insulin、growth hormone and cortisol in premature infants with intrauterine[J]. .

姚明珠,陆国强,陈豪,印学蕾,吴莉,戴芸佳,郭佳林,丁效薇,胡勇,徐秋玲. 宫内发育迟缓早产儿胰岛素生长激素及皮质醇的变化和发病关系研究[J]. 中国实用儿科杂志.

[1]	WU Wei，LUO Xiao-ping. Interpretation of Expert Consensus on the Diagnosis and Management of Growth Hormone Deficiency during the Transition Period [J]. CJPP, 2021, 36(8): 565-569.
[2]	XI Li， LUO Fei-hong. A hormonal approach to the evaluation of short stature [J]. CJPP, 2021, 36(8): 581-585.
[3]	CHENG Xin-ran，LENG Jie. GH-IGF-I axis signaling pathway and paracrine signaling pathways in the pathogenesis of growth disorder [J]. CJPP, 2021, 36(8): 592-597.
[4]	QIN Miao，GONG Chun-xiu. Growth hormone deficiency and nonalcoholic fatty liver disease [J]. CJPP, 2021, 36(8): 597-602.
[5]	WEI Hai-yan. Benefits and risks of growth hormone therapy based on evidence-based medicine [J]. CJPP, 2021, 36(8): 607-612.
[6]	HUANG Shu-yue， CHEN Xiao-bo， SONG Fu-ying， et al. A study on serum glucagon level in hypoglycemia children [J]. CJPP, 2021, 36(6): 447-451.
[7]	SU Chang, GONG Chun-xiu. Research advances in diagnosis and treatment of hyperinsulinemia-hyperammonemia syndrome [J]. Chinese Journal of Practical Pediatrics, 2021, 36(10): 748-752.
[8]	SHI Lin， DENG Yan-jun. Serotonin, prolactin and cortisol and vasovagal syncope [J]. CJPP, 2020, 35(8): 595-599.
[9]	ZHANG Ya-nan，ZHANG Hui-feng. Congenital hyperinsulinemia misdiagnosed as epilepsy [J]. CJPP, 2020, 35(7): 514-517.
[10]	WANG Chun-lin*，FU Jun-fen，LIANG Li. Advances in the study of drugs to improve growth of children with short stature [J]. CJPP, 2020, 35(6): 460-464.
[11]	LIU Jing， QIU Ru-xin，GAO Yue-qiao. Application of lung ultrasound in diagnosis of bronchopulmonary dysplasia in premature infants [J]. CJPP, 2020, 35(2): 97-100.
[12]	ZHANG Ying，CHEN Rui-min，YANG Xiao-hong，et al. Clinical analysis of the recombinant human growth hormone combined with letrozole in the treatment of short pubertal boys [J]. CJPP, 2019, 34(9): 775-779.
[13]	LI Hui. Short stature and standardized use of growth hormone [J]. CJPP, 2019, 34(10): 815-818.
[14]	TONG Mei-ling. Premature and low birth weight infants: Postnatal visual health care [J]. CJPP, 2019, 34(10): 833-837.
[15]	ZHANG Wei，SANG Yan-mei. Genetic pathogenesis and the progress in the diagnosis and treatment of congetinal glucokinase hyperinsulinism [J]. CJPP, 2018, 33(6): 468-472.