Chinese Journal of Practical Pediatrics

Chinese Journal of Practical Pediatrics ›› 2025, Vol. 40 ›› Issue (6): 497-501.DOI: 10.19538/j.ek2025060611

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Comparison and interpretation of treatment for group A streptococcus pharyngitis in different diagnosis and treatment guidelines

  

  1. *Key Laboratory of Major Diseases in Children，Ministry of Education，National Clinical Research Center for Respiratory Diseases，National Key Discipline of Pediatrics，Laboratory of Infection and Microbiology，Beijing Pediatric Research Institute，Beijing Children’s Hospital，Capital Medical University，National Center for Children’s Health，Beijing  100045，China
  • Online:2025-06-06 Published:2025-08-29

不同 A 族链球菌咽炎诊治指南治疗部分的比较与解读

  

  1. 1. 国家儿童医学中心  首都医科大学附属北京儿童医院  北京市儿科研究所感染与微生物研究室  国家呼吸系统疾病临床医学研究中心  儿科学国家重点学科  儿科重大疾病研究教育部重点实验室，北京  100045 ；2. 首都医科大学石景山教学医院  北京市石景山医院儿科，北京  100043 ；3. 浙江大学医学院附属邵逸夫医院  新疆兵团阿拉尔医院儿科，新疆  阿拉尔  843300 ； 4. 国家儿童医学中心  首都医科大学附属北京儿童医院风湿科，北京  100045
  • 通讯作者: 姚开虎，电子信箱：yaokaihu@bch.com.cn
  • 基金资助:
    兵团财政科技计划项目 南疆重点产业创新发展支撑计划（2021DB020）

Abstract: Group A streptococcus (GAS) is the most common bacterial pathogen of pharyngitis. Unlike other causes of pharyngitis， untreated or poorly treated GAS pharyngitis can often lead to a variety of complications， resulting in a serious disease burden. As a typical self-limiting disease， the treatment goals for GAS pharyngitis include symptom relief， shortening disease duration， preventing complications， and reducing bacterial transmission risks. Recommendations from different guidelines regarding GAS pharyngitis management remain inconsistent， with ongoing debates about the necessity for antimicrobial therapy， optimal timing for using antibiotics， and specific medication regimens， and there is not a clearly dominant therapeutic approach. When considering antimicrobial treatment for patients with GAS pharyngitis， careful evaluation of local GAS complication prevalence and individual patient risks is essential. Additionally， personalized management and treatment strategies are required for special patient groups related to GAS pharyngitis， such as GAS carriers， patients with recurrent infections， and those at high risk of acute rheumatic fever.

Key words: group A streptococcus, pharyngitis, drug treatment, antibiotics, prevention

摘要： A 族链球菌 (group A streptococcus，GAS) 是咽炎最常见的细菌性病原。与其他原因咽炎不同，未及时治疗或治疗不规范的 GAS 咽炎可能引起多种并发症，造成严重的疾病负担。GAS 咽炎是典型的自限性疾病，治疗目的包括缓解症状、缩短病程、预防并发症、减少细菌传播风险等。关于如何治疗 GAS 咽炎，不同指南的推荐意见并不完全一致，是否需要使用抗菌药物治疗、何时使用抗菌药物以及用药方案存在分歧，目前并没有明显占优势的治疗建议。在考虑应用抗菌药物治疗 GAS 咽炎患者时，应充分评估当地 GAS 并发症的流行情况和患者的个体风险。此外，对于一些 GAS 咽炎相关的特殊患者，如 GAS 携带者、复发性感染患者和 ARF 高风险患者，需要个性化的管理和治疗策略。

关键词: A 族链球菌, 咽炎, 药物治疗, 抗生素, 预防