Abstract: Metabolic bone diseases are characterized by atyp-ical early onset complex clinical manifestations in the middle and late stages. The patients usually present with growth disorders，osteoarthropathy and skeletal deformities. Some patients have multiple organ damage with high disability and mortality. Early identification，correct diagnosis，rational treatment， and health management are important to improve the outcome of the patients with metabolic bone diseases. Nutritional and metabolic support is the key strategy for the prevention and treatment of metabolic bone diseases. Due to congenital and acquired defects，patients with metabolic bone diseases need individualized calcium，phosphorus，vitamin D，collagen and hormone support. Regular diet cannot meet the needs of patients，and special nutritional metabolic support is required for the treatment. The article will summarize and elaborate around the nutritional metabolic support of common metabolic bone diseases from their clinical manifestations and current research status.

Key words: metabolic bone disease, nutrition support, nutri-ents, vitamin D

摘要： 代谢性骨病早期发病特征不典型，中后期临床表现复杂，常见生长障碍、骨关节病、骨骼畸形，一些患者合并多器官损害，致残及致死率均较高，因此，早期识别、正确诊断、合理治疗、健康管理对改善代谢性骨病患者转归有重要意义。营养代谢支持是预防和治疗代谢性骨病的重要措施。由于先天及后天缺陷，代谢性骨病患者需要个体化的钙、磷、维生素D、胶原蛋白及激素支持，正常饮食不能满足患者需求，需要特殊营养代谢支持治疗。文章将从常见代谢性骨病的临床表现及研究现状出发，围绕其营养代谢支持治疗进行总结及阐述。

关键词: 代谢性骨病, 营养, 营养素, 维生素D