Abstract:

Bronchiolitis obliterans is associated with many factors；clinical common causes include infection，allogeneic hematopoietic stem cell transplantation，allogeneic organ transplantation，inhalation injury and autoimmune diseases，such as adverse drug reactions. The main pathogenesis is that the airway epithelial tissue is excessively activated by the tissue injury resulting from inflammation or immune response which triggered a series of related immune response，accompanied by respiratory function recovery disorder，eventually leading to the occurrence of BO.

Key words: bronchiolitis obliterans, etiology, pathogenesis

摘要：

闭塞性细支气管炎（BO）的发生与许多因素相关，临床常见病因包括感染、异体造血干细胞移植、异体器官移植、吸入性损伤、自身免疫性疾病、药物不良反应等。其发病机制主要是气道上皮在炎症或免疫反应所导致的组织损伤作用下被过度激活，从而引发一系列相关免疫反应，同时伴有呼吸道功能修复障碍，最终导致BO的发生。

关键词: 闭塞性细支气管炎, 病因, 发病机制