Expert consensus on individualized dosing of tacrolimus for pediatric glomerular diseases

doi:10.19538/j.ek2025010601

Chinese Journal of Practical Pediatrics ›› 2025, Vol. 40 ›› Issue (1): 1-12.DOI: 10.19538/j.ek2025010601

Online:2025-01-06 Published:2025-02-26

他克莫司治疗儿童肾小球疾病的个体化用药专家共识

执　笔：莫小兰，黄凌斐，赵一鸣，曹　娟，谢　萍，王晓玲
制订专家（按姓氏汉语拼音首字母顺序排序）：蔡和平（安徽省儿童医院）；曹　娟（江西省儿童医院）；陈　孝（中山大学附属第一医院）；陈　峰（南京医科大学附属儿童医院）；陈　攀（中山大学附属第一医院）；陈文倩（中日友好医院）；陈泽彬（深圳市儿童医院）；方晓燕（复旦大学附属儿科医院）；范晓梅（深圳市宝安区妇幼保健院）；高　霞（广州医科大学附属妇女儿童医疗中心）；黄晨蓉（苏州大学附属第一医院）；黄凌斐（浙江大学医学院附属儿童医院）；贾运涛（重庆医科大学附属儿童医院）；李嘉丽（中山大学药学院）；李亦蕾（南方医科大学南方医院）；李志玲（上海交通大学医学院附属上海儿童医学中心）；李　中（大连市妇女儿童医疗中心（集团）；李学娟（深圳市儿童医院）；林芸竹（四川大学华西第二医院）；吕　萌（河南省儿童医院）；马葵芬（浙江大学医学院附属第一医院）；毛建华（浙江大学医学院附属儿童医院）；缪　静（浙江大学医学院附属儿童医院）；莫小兰（广州医科大学附属妇女儿童医疗中心）；彭晓霞（首都医科大学附属北京儿童医院）；沈　茜（复旦大学附属儿科医院）；王晓玲（首都医科大学附属北京儿童医院）；王学彬（上海市儿童医院上海交通大学医学院附属儿童医院）；汪　洋（华中科技大学同济医学院附属武汉儿童医院）；吴洋意（《中国实用儿科杂志》编辑部）；夏正坤（中国人民解放军东部战区总医院）；谢　萍（广州医科大学附属妇女儿童医疗中心）；谢悦良（中南大学湘雅三医院）；张毕奎（中南大学湘雅二医院）；赵立波（北京大学第三医院）；赵　维（山东大学临床药理研究所）；赵一鸣（首都医科大学附属北京儿童医院）；肇丽梅（中国医科大学附属盛京医院）；张　涛（广州医科大学附属妇女儿童医疗中心）；郑志华（广东省药学会）；周　红（华中科技大学同济医学院附属协和医院）

通讯作者: 莫小兰，电子信箱：allenmor@163.com；王晓玲，电子信箱：wangxiaoling@bch.com.cn

Abstract

Abstract: Tacrolimus is a widely used immunosuppressant in the treatment of pediatric glomerular diseases. However，precision dosing presents a challenge due to significant individual differences in pharmacokinetics and pharmacodynamics. Currently， there are no guidelines for individualized dosing of tacrolimus in the treatment of pediatric glomerular diseases， either domestically or internationally. With the aim of assisting physicians and pharmacists in implementing individualized dosing and improving patient satisfaction， the consensus， summarizes the application of tacrolimus in pediatric glomerular diseases， its concentration monitoring， pharmacogenetic testing， and pharmaceutical care based on the latest research advancements and clinical practice experience both domestically and internationally.

Key words: tacrolimus, child, glomerular diseases, individu-alized medicine, pharmaceutical care

摘要： 他克莫司是儿童肾小球疾病治疗中被广泛应用的免疫抑制剂，由于药代动力学、药效动力学的个体差异大，精准用药面临困境。国内外尚缺乏他克莫司治疗儿童肾小球疾病的个体化用药指引。该共识结合国内外最新研究进展和临床实践经验，从他克莫司在儿童肾小球疾病中的应用、血药浓度监测、药物基因检测和药学监护几方面进行总结，以期协助医师、药师开展个体化用药，提高患者满意度。

关键词: 他克莫司, 儿童, 肾小球疾病, 个体化用药, 药学监护

Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society, Guangdong Pharmaceutical Association, Editorial Committee of Chinese Journal of Practical Pediatrics. Expert consensus on individualized dosing of tacrolimus for pediatric glomerular diseases[J]. Chinese Journal of Practical Pediatrics, 2025, 40(1): 1-12.

中国药理学会治疗药物监测研究专业委员会, 广东省药学会, 《中国实用儿科杂志》编辑委员会. 他克莫司治疗儿童肾小球疾病的个体化用药专家共识[J]. 中国实用儿科杂志, 2025, 40(1): 1-12.

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