Abstract: Sepsis is a common cause of death in children.Immune inflammatory response is a key mechanism in the pathogenesis of sepsis.Sepsis with different stages of disease， excessive proinflammatory compensatory anti-inflammatory response and reaction causes the immune system balance， eventually leading to immune. Comprehensive understanding of children sepsis immune inflammatory response and development，attaches great importance to the children of sepsis immune dynamic evaluation， is advantageous to the precise treatment and individualized treatment， diagnosis and treatment to improve children's sepsis，improve disease and after， and to reduce the financial burden of medical purpose.

Key words: pediatric sepsis, immune inflammation, evalu-ation, intervention strategy

摘要： 儿童脓毒症是儿童死亡的常见原因。免疫炎症反应是脓毒症发病机制中的关键一环。脓毒症具有不同的疾病阶段，过度的促炎反应和代偿性抗炎反应导致免疫系统稳态失衡，最终导致免疫损伤。全面认识儿童脓毒症免疫炎症反应和发生发展，重视儿童脓毒症的免疫动态评价，有利于精准治疗和个体化治疗，达到提高儿童脓毒症诊疗水平，改善疾病与预后、减轻医疗负担的目的。

关键词: 儿童脓毒症, 免疫炎症, 评价, 干预策略