Abstract: Sepsis is considered tobe a global health problem， with patients dying from sepsis accounting for almost 20% of all deaths worldwide each year. Due to the development featuresof immune system， children have a higher chance of infection in respiratory system， digestive system and nervous system than adults， and are easy to develop sepsis after infection. At present， the sepsisin children isgaining increasing social concern， and its higher mortality rate has not decreased with increased awareness. With the development of material science， more and more new techniques and new materials are applied to the manufacture of blood purificationfilters. This allows us to intervene from a specific step in a complex immune process of pathogens， leukocytes， endotoxins， cytokines， etc. Blood purification is given high expectation toin the treatment of sepsis. This paper will introduce the selection of blood purification modes and filters from various stages of the occurrence and development of sepsis.

Key words: child, sepsis, blood purification

摘要： 脓毒症被认为是一个全球性健康问题，每年因脓毒症死亡患者占全球死亡总数的近20%。儿童由于免疫系统发育特点，有比成人更高的呼吸系统、消化系统、神经系统等感染概率，感染后容易发展为脓毒症。目前儿童脓毒症越来越受到社会关注，但其较高的病死率并未因认识加深而下降。随着材料科学的发展，越来越多的新工艺、新材料被应用于血液净化滤器的制造中，这使从病原、白细胞、内毒素、细胞因子等复杂免疫过程中的一个特定步骤进行干预成为可能。脓毒症的治疗中血液净化被寄予厚望。文章将从脓毒症发生、发展的各个环节，介绍血液净化模式及滤器的选择。

关键词: 儿童, 脓毒症, 血液净化