Chinese Journal of Practical Pediatrics ›› 2024, Vol. 39 ›› Issue (4): 249-254.DOI: 10.19538/j.ek2024040602

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Expert consensus on diagnosis and treatment of Talaromyces marneffei infection in children (Guangdong) 

  

  • Online:2024-04-06 Published:2024-05-08

儿童马尔尼菲篮状菌感染诊治专家共识(广东)

  

  1. 执 笔:黄柳一,黄花荣,王文建,王桂兰,岳智慧,徐雪花,李洪伟,陈德晖,卢 根
    制定专家(排名不分先后):中山大学附属第一医院(黄柳一,岳智慧);深圳市儿童医院(王文建);佛山市妇幼保健院(白 珺);汕头大学医学院第二附属医院(林创兴);深圳市妇幼保健院(赵宏霞);中山大学孙逸仙纪念医院(黄花荣);东莞市妇幼保健院(马战英);肇庆市第一人民医院(陈智锋);广州医科大学附属广州市妇女儿童医疗中心(卢 根,徐雪花,戴望春);广东医科大学附属医院(柯创宏);广州医科大学附属第一医院(陈德晖,李洪伟,陈晓雯);江门市妇幼保健院(吴振波);南方医科大学附属广东省人民医院(陈永新);中山市博爱医院(王桂兰);汕头大学医学院附属粤北人民医院(肖小兵);中山大学附属第三医院(陈奋华)
  • 通讯作者: 卢根,电子信箱:lugen5663330@sina.com;陈德晖,电子信箱:cdh84@126.com

Abstract: Talaromyces marneffei is an endemic opportunistic pathogenic fungus that is mainly prevalent in Guangdong and Guangxi regions in China.Different from Talaromyces marneffei infection in adults that are more common in patients with HIV infection,in children it is more common in immunocompromised patients without HIV infection.Due to the lack of specific clinical manifestations and insufficient understanding of the disease,it is easy to make misdiagnosis or missed diagnosis,leading to incre-ased mortality. In this article the related etiology,epidemiology,pathogenic mechanism,clinical manifestations,auxiliary exami-nation,diagnosis and treatment are described,in order to improve the doctors’ level in the diagnosis and treatment of this disease.

Key words: child, Talaromyces marneffei, expert consensus

摘要: 马尔尼菲篮状菌是一种地方性机会致病性真菌,在中国主要流行于广东和广西地区。不同于成人马尔尼菲篮状菌感染多见于人类免疫缺陷病毒(HIV)感染者,儿童马尔尼菲篮状菌感染多见于非HIV感染的免疫功能低下者。由于缺乏特异性临床表现,对其认识不足,容易出现漏诊或误诊,病死率高。文章对儿童马尔尼菲篮状菌相关病原学、流行病学、致病机制、临床表现、辅助检查、诊断和治疗等内容进行阐述,以期提高临床医师对疾病诊断及治疗水平。

关键词: 儿童, 马尔尼菲篮状菌, 专家共识