Abstract: Atopic dermatitis is a recurrent， chronic and non-infectious inflammatory skin disease，which is common in children.AD has a close relationship with allergen sensitization. Oral tolerance induction therapy is an approach to establish immune tolerance by the active suppression of antigen-specific immune responses in the gastrointestinal tract. OTI has been used to intervene various atopic diseases， and may become a new strategy to prevent and treat AD.

Key words: atopic dermatitis, oral tolerance induction, Th2 immune response

摘要： 特应性皮炎（atopic dermatitis， AD）是儿童常见的一种反复发作的、慢性、非感染性的炎症性皮肤病。AD与变应原致敏之间存在密切联系。口服耐受诱导疗法（oral tolerance induction，OTI）是通过主动抑制胃肠道对于抗原的特异性反应而建立免疫耐受的过程，目前已经被应用于干预多种特应性疾病，可能成为防治AD的新策略。

关键词: 特应性皮炎, 口服免疫耐受, Th2型免疫反应