Abstract:

Inflammatory bowel disease（IBD），including ulcerative colitis（UC） and Crohn’s disease（CD），is a chronic relapsing inflammatory disorder of the gastrointestinal tract. Probiotics could be of benefit since involvement of the microbiota in the pathogenesis of IBD is evident. Although some promising studies are underway，the evidence for probiotics is still insufficient to recommend its use for IBD in daily clinical practice. Available data showed that the primary outcomes were correlated with probiotic strains and dosages. In general，probiotics have proven valuable in the management of ulcerative colitis. However，the probiotics seem to confer little benefit in Crohn’s disease.

Key words: inflammatory bowel disease, probiotics, child

摘要：

炎症性肠病（inflammatory bowel disease， IBD）是一组病因未明的慢性非特异性肠道炎性疾病，主要包括溃疡性结肠炎（ulcerative colitis，UC ）和克罗恩病（Crohn’s disease，CD）。随着人们对肠道微生物在IBD发病中认识的加深，益生菌在儿童IBD治疗中显示出良好的前景，但目前仍缺乏高质量证据确证益生菌菌株疗效，指导临床对益生菌菌种、摄入方式、剂量等进行选择。现有研究表明，益生菌发挥治疗作用存在菌株特异性，且在诱导UC缓解、维持UC缓解以及预防贮袋炎方面的效果更为明显，但益生菌诱导CD、维持CD缓解和预防CD术后复发的效果并不理想。

关键词: 炎症性肠病, 益生菌, 儿童