关键词: 白血病, 儿童, 精准医学, NGS-微小残留病, 单细胞组学, 双特异抗体, 抗体药物偶联物, 嵌合抗原受体T细胞治疗

Abstract: This article focuses on three main lines：precise diagnosis，precise treatment，and precise management. By integrating recent key clinical trials and mechanism studies，it mainly discusses the selection of clinically feasible strategies，toxicity balance，and future challenges. It emphasizes that precision medicine for childhood leukemia will further progress from genotyping-driven to pan-genomics and intelligent decision-making era，ultimately achieving the long-term goal of equally prioritizing cure rate and quality of life.

Key words: leukemia, child, precision medicine, NGS-MRD, single-cell omics, bispecific antibody, antibody drug conjugate, CAR-T