中国实用儿科杂志

中国实用儿科杂志 ›› 2024, Vol. 39 ›› Issue (9): 679-685.DOI: 10.19538/j.ek2024090607

• 专题笔谈 • 上一篇    下一篇

儿童脓毒症凝血病干预策略

  

  1. 苏州大学附属儿童医院重症医学科，江苏  苏州  215003
  • 出版日期:2024-09-06 发布日期:2024-09-23
  • 通讯作者: 柏振江，电子信箱：bbyshu@hotmail.com

Intervention strategy for coagulopathy in children with sepsis

  1. Pediatric Intensive Care Unit， Children's Hospital of Soochow University，Suzhou  215003，China
  • Online:2024-09-06 Published:2024-09-23

摘要： 儿童脓毒症是一种危及生命的疾病，常伴有严重凝血功能障碍，即脓毒症诱发的凝血病（SIC），由复杂的炎症和凝血系统失调引起，这一过程涉及炎症介质的释放、凝血系统的激活、纤溶系统的抑制、抗凝机制的受损、内皮细胞的功能障碍以及血小板的异常等机制。SIC在儿童中表现出高发生率和高病死率，及时有效的干预对改善预后至关重要。

关键词: 脓毒症, 凝血功能障碍, 凝血病, 弥散性血管内凝血

Abstract: Sepsis is a life-threatening disease， which is often accompanied by severe coagulation disorders， known as sepsis-induced coagulopathy （SIC）. This condition results from complex dysregulation of the inflammatory and coagulation systems， involving the release of inflammatory mediators， activation of the coagulation system， inhibition of the fibrinolytic system， impairment of anticoagulant mechanisms， endothelial dysfunction， and platelet abnormalities. SIC in children is characterized by high incidence and mortality rates. Timely and effective intervention is crucial for improving outcomes. 

Key words: sepsis, coagulation disorders, coagulopathy, disseminated intravascular coagulation