中国实用儿科杂志

中国实用儿科杂志 ›› 2024, Vol. 39 ›› Issue (9): 699-704.DOI: 10.19538/j.ek2024090611

• 专题笔谈 • 上一篇    下一篇

儿童脓毒症的免疫炎症损伤评价与干预

  

  1. 1.复旦大学附属儿科医院重症医学科，上海  201102；2.上海市重大传染病和生物安全研究院， 上海  200032
  • 出版日期:2024-09-06 发布日期:2024-09-24
  • 通讯作者: 陆国平，电子信箱：13788904150@163.com
  • 基金资助:
    国家重点研发计划（2021YFC2701800，2021YFC2701802，2021YFC2701805）；上海市卫生健康系统重点扶持学科项目（2023ZDFC0103）

Immune inflammatory injury of sepsis in children and the evaluation and intervention 

  1. *Department of Critical Care Medicine， Children's Hospital of Fudan University， Shanghai  201102， China
  • Online:2024-09-06 Published:2024-09-24

摘要： 儿童脓毒症是儿童死亡的常见原因。免疫炎症反应是脓毒症发病机制中的关键一环。脓毒症具有不同的疾病阶段，过度的促炎反应和代偿性抗炎反应导致免疫系统稳态失衡，最终导致免疫损伤。全面认识儿童脓毒症免疫炎症反应和发生发展，重视儿童脓毒症的免疫动态评价，有利于精准治疗和个体化治疗，达到提高儿童脓毒症诊疗水平，改善疾病与预后、减轻医疗负担的目的。

关键词: 儿童脓毒症, 免疫炎症, 评价, 干预策略

Abstract: Sepsis is a common cause of death in children.Immune inflammatory response is a key mechanism in the pathogenesis of sepsis.Sepsis with different stages of disease， excessive proinflammatory compensatory anti-inflammatory response and reaction causes the immune system balance， eventually leading to immune. Comprehensive understanding of children sepsis immune inflammatory response and development，attaches great importance to the children of sepsis immune dynamic evaluation， is advantageous to the precise treatment and individualized treatment， diagnosis and treatment to improve children's sepsis，improve disease and after， and to reduce the financial burden of medical purpose.

Key words: pediatric sepsis, immune inflammation, evalu-ation, intervention strategy