关键词: 磁共振, 多模态, 脑病, 新生儿

Abstract: There are many kinds of encephalopathy in neonatal period，such as hypoxic ischemic encephalopathy，bilirubin encephalopathy，hypoglycemic encephalopathy，encephalopathy of prematurity，sepsis-associated enceph-alopathy，hereditary metabolic encephalopathy，mitochondrial encephalopathy and so on. Magnetic resonance imaging（MRI） can be used to diagnose and evaluate the disease，which is an ideal imaging method. Conventional MRI is most widely used，however，it is often difficult to achieve the purpose of early diagnosis and accurate identification，as well as cerebral function evaluation. Currently，a variety of MRI techniques have been developed，including diffusion weighted imaging，diffusion tensor imaging，magnetic sensitivity weighted imaging，proton magnetic resonance spectroscopy imaging，fluid attenuated inversion recovery and so on，which are collectively known as multimodal MRI technology. These techniques have the advantages of high sensitivity，strong specificity，high signal contrast，reflecting the metabolic level of brain tissue and so on，which can make up for the shortcomings of conventional MRI techniques. It has a broad application prospect for early diagnosis and differentiation of neonatal encephalopathy，evaluation of brain function and prognosis judgment.

Key words: magnetic resonance imaging, multimode, enceph-alopathy, neonate