关键词: 乌司他丁, 新生儿, 坏死性小肠结肠炎, 血流动力学

Abstract: Objective　To investigate the hemodynamic effects of ulinastatin on neonatal necrotizing enterocolitis（NEC） and the effectiveness of clinical treatment. Methods　A reprospective study was adopted. A total of 150 cases of neonatal necrotizing enterocolitis were chosen，who were clinically diagnosed in Xi 'an Children's Hospital from August 2016 to January 2020. 30 cases in the observation group were treated with ulinastatin，and the other 120 cases without ulinastatin were used as the control group. Demographic baseline data of the two groups were collected，the changes in clinical biochemical indexes before and 48 h after treatment were compared between the two groups. The changes in hemodynamic indexes in the observation group at different time points of ulinastatin injection were continuously measured. At the same time，compare the hemodynamic changes at 24h and 48h after medication between the two groups，and compare the difference in hospitalization as well. Results　After 48 hours of treatment，the levels of prothrombin time（PT），partial thrombin time（APTT），D-dimer（D-D），serum creatinine（Scr），serum lactate（Lac），serum precalcitonin（PCT），interleukin-6 （IL-6）and interleukin-8 （IL-8） were all lower than those before treatment，in the observation group（all P<0.05） while APTT，D-dimer，PCT，IL-6 and I L-8 in the control group were higher than those before treatment（all P<0.05）. The PT，APTT，D-dimer，Scr，Lac，PCT，IL-6，IL-8 in the observation group were lower than those in the control group at 48 hours after treatment. After 48 h of treatment，the incidence of blood stool，abdom-inal distension，bowel sound attenuation，abdominal ultrasound and abdominal tablet abnormality in the observation group was all lower than that before treatment and in the control group （all P<0.05）. In the observation group，after 30 minutes in ulinastatin，the changes of hemodynamic indexes were not significant. After 60 minutes of medication，hemodynamics tended to improve and gradually remained stable .The difference in continuous measurement within the group was statistically significant（all P<0.05）. Compared with the control group，the fasting time，length of hospital stay，incidence of surgical operation and mortality were all decreased in the observation group （all P<0.05）. Conclusion　Ulinastatin can improve hemodynamics by reducing the inflammatory response of the body，and reduce the fasting time，hospitalization time，incidence of surgery and mortality of neonatal necrotizing enterocolitis.

Key words: ulinastatin, neonate, necrotizing enterocolitis, hemodynamics