中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (5): 349-353.DOI: 10.19538/j.ek2023050606

• 专题笔谈 • 上一篇    下一篇

新生儿脑病及脑发育的床旁脑功能成像

  

  1. 北京大学第一医院儿科，北京  100034
  • 出版日期:2023-05-06 发布日期:2023-06-12
  • 基金资助:
    国家重点研发计划（2021YFC2700700）；中央高水平医院临床科研业务费资助（北京大学第一医院高质量临床研究专项2022CR68）

Bedside brain function imaging of neonatal encephalop-athy and brain development 

  1. Department of Pediatrics，Peking University First Hospital，Beijing  100034，China
  • Online:2023-05-06 Published:2023-06-12

摘要： 新生儿脑病与脑发育的床旁功能成像，为神经多模态监护之一。在显示脑结构的同时，检测脑血流动力学变化，反映脑功能。目前已临床使用的是近红外光谱脑氧成像和功能超声成像。两者均是基于神经血管耦合的原理，通过光或超声“看”到脑血流变化；根据血流改变，“看”到脑功能活动。近红外脑氧可实现脑皮层成像，通过国际10-20导联，对脑皮层行细化分区。功能超声可实现皮层及皮层下大视场（数厘米）功能成像，检测脑微血管血流动力学改变。

关键词: 新生儿脑病, 脑发育, 脑功能成像

Abstract: Bedside functional imaging in neonatal encepha-lopathy and brain development is an important part of neurological multimodal monitoring. Cerebral hemodynamics are detected to reflect brain function，while at the same time displaying brain structure. Near-infrared spectroscopy cerebral oxygen imaging and functional ultrasound imaging are currently used clinically. Both modalities are based on the principle of neurovascular coupling，"observing" changes in cerebral blood flow through light or ultrasound，and reflecting brain functional activity according to changes in blood flow. Near-infrared cerebral oxygen imaging monitoring can realize cerebral cortex imaging，and through the international 10-20 leads，the cerebral cortex can be refined and divided. Functional ultrasound can realize functional imaging of large cortical and subcortical fields of view （several centimeters）， detecting cerebral microvascular hemodynamic changes.

Key words: neonatal encephalopathy, brain development, brain functional imaging