中国实用儿科杂志

中国实用儿科杂志 ›› 2023, Vol. 38 ›› Issue (2): 93-98.DOI: 10.19538/j.ek2023020604

• 专题笔谈 • 上一篇    下一篇

儿童体外膜氧合的抗凝管理

  

  1. 1.兰州大学第二医院儿童重症科，甘肃  兰州  730000；2.西安交通大学附属儿童医院儿童重症科，陕西  西安  710003
  • 出版日期:2023-02-06 发布日期:2023-03-09
  • 通讯作者: 王义，电子信箱：wangyichengxian@163.com
  • 基金资助:
    国家重点研发计划项目（2021YFC2701700）；首都卫生发展科研专项项目（2020-2-5093）

Anticoagulation management in pediatric extracorporeal membrane oxygenation

  1. *The PICU of the Second Hospital of Lanzhou University，Lanzhou  730000，China
  • Online:2023-02-06 Published:2023-03-09

摘要： 体外膜氧合（ECMO）技术已经成为成人及儿童重症监护病房必不可少的关键技术，是严重呼吸衰竭和（或）循环衰竭的终极治疗手段。ECMO期间出血及血栓等凝血系统并发症是影响患者死亡的主要因素之一。目前关于ECMO的最佳抗凝策略尚无统一标准。该文就儿童ECMO期间的抗凝药物及监测方法进行讨论，探讨如何把ECMO期间的抗凝管理做到最佳。

关键词: 体外膜氧合, 儿科, 抗凝, 抗Xa, 直接凝血酶抑制剂

Abstract: Extracorporeal membrane oxygenation（ECMO） has become a critical and essential technology in adult and pediatric intensive care units and is the ultimate treatment for severe respiratory and/or circulatory failure. Complications related to the coagulation system such as bleeding and thrombosis during ECMO are one of the main factors affecting the mortality of patients. There is no unified standard on the best anticoagulant strategy for ECMO. This paper reviews the research progress of anticoagulation management and monitoring methods during ECMO in children，and discusses how to achieve the best anticoagulation management during ECMO.

Key words: ECMO, pediatric, anticoagulation, anti-Xa, direct thrombin inhibitors