中国实用儿科杂志

中国实用儿科杂志 ›› 2025, Vol. 40 ›› Issue (9): 728-734.DOI: 10.19538/j.ek2025090605

• 专题笔谈 • 上一篇    下一篇

全身型幼年特发性关节炎分类诊断与治疗管理

  

  1. 重庆医科大学附属儿童医院风湿免疫科  儿童感染免疫重庆市重点实验室  儿童发育疾病研究教育部重点实验室  国家儿童健康与疾病临床医学研究中心  儿童发育重大疾病国家国际科技合作基地，重庆  400014
  • 出版日期:2025-09-06 发布日期:2025-10-20
  • 通讯作者: 唐雪梅，电子信箱：tangxuemei2008@163.com
  • 基金资助:
    国家重点研发计划项目（2021YFC2702003）

Classification diagnosis and treatment management of systemic juvenile idiopathic arthritis

  1. Department of Rheumatology and Immunology，Chongqing Key Laboratory of Child Infection and Immunity，Ministry of Education Key Laboratory of Child Development and Disorders，National Clinical Research Center for Child Health and Disorders， Children’s Hospital of Chongqing Medical University，China International Science and Technology Cooperation Base of Child and Critical Disorders. Chongqing  400014，China
  • Online:2025-09-06 Published:2025-10-20

摘要： 全身型幼年特发性关节炎（systemic juvenile idiopathic arthritis，sJIA）具有独特的疾病背景和临床特点，有多种关节外表现和疾病模式。sJIA病因尚未明确，存在先天与后天因素的共同作用。炎症控制和靶向治疗是实现疾病缓解的关键。文章主要介绍了sJIA的发病机制、分类标准及目前诊疗相关研究进展，全球主要达标治疗管理原则，强调了早期诊断、精准干预及远期随访对改善患者预后、提高生活质量的重要作用，有助于进一步加深临床医生对sJIA的整体认识。

关键词: 全身型幼年特发性关节炎, 机制, 分类诊断, 靶向治疗

Abstract: Systemic juvenile idiopathic arthritis（sJIA）has a unique disease background and clinical profile，with various extra-articular manifestations and disease patterns. Its etiology remains unclear. The interaction between genetic and environmental factors contributes to the onset and progression of the disease. Inflammation control and targeted therapies are key to achieving disease remission. This review outlines the pathogenesis of sJIA，classification criteria，current research advances in diagnosis and treatment，and the main global principles for targeted therapeutic management，highlighting the importance of early diagnosis，precise intervention，and long-term follow-up in improving patient outcomes and quality of life，which helps to deepen clinicians’ overall understanding of sJIA.

Key words: systemic juvenile idiopathic arthritis, mechanism, classification diagnosis, targeted therapy