关键词: 人类疱疹病毒6型, 高通量测序, 髓鞘少突胶质细胞糖蛋白

Abstract: The article retrospectively analyzed the clinical data of a pediatric patient with HHV-6 encephalitis combined with MOG antibody-associated disease and reviewed relevant literature. The patient was an 11-year-old girl with acute onset，rapidly presenting with convulsions and coma. Mild cerebrospinal fluid pleocytosis was observed，and next-generation sequencing（NGS）of pathogenic microorganism nucleic acids in cerebrospinal fluid showed a large number of HHV-6. The serum MOG antibody titer was 1:10. MRI revealed extensive inflammatory and demyelinating lesions in the brain parenchyma，optic nerve，and cervical spinal cord. Following treatment with methylprednisolone pulse therapy，intravenous immunoglobulin，and ganciclovir，the patient achieved complete neurological recovery，with significant improvement on imaging. Two case reports on HHV-6 infection complicated with MOG antibody-associated disease were retrieved from the literature，all of which had favorable prognoses after antiviral therapy combined with early immunotherapy. When demyelinating changes are present in HHV-6 encephalitis children with normal immune function，the possibility of concurrent MOG antibody-associated disease should be considered. Early and precise diagnosis can be achieved using cerebrospinal fluid NGS combined with demyelinating antibody detection.

Key words: