Abstract:

Objective    To evaluate the clinical outcomes of non-surgical mechanical and Nd∶YAG laser therapy plus local applied minocycline hydrochloride on initial peri-implantitis. Methods    Totally 40 implants from 26 patients diagnosed with initial peri-implantitis in the Department of Periodontology，Hospital of Stomatology，China Medical University from February 2013 to June 2014，were enrolled and randomly assigned to 2 groups：laser  therapy group and control group，and 20 implants per group. Implants in control group were treated with non-surgical periodontal therapy and local applied minocycline hydrochloride. Implants in laser therapy group received Nd∶YAG laser therapy based on the control group. Modified plaque index（mPLI），modified sulcus bleeding index（mSBI）and probing depth（PD）were measured at baseline and 8 weeks after therapy. Results    After 8 weeks，implants of both groups yielded a statistically significant reduction（P < 0.05）in mPLI，mSBI and PD，when compared with baseline. Between-group comparisons revealed statistically significant differences in mSBI and PD （P < 0.05） at 8 weeks after therapy. Conclusion    Non-surgical mechanical and Nd∶YAG laser therapy plus local applied minocycline hydrochloride is effective for initial peri-implantitis.

Key words: peri-implantitis, laser, minocycline hydrochloride

摘要：

目的    评价机械治疗+ Nd∶YAG 激光+局部应用盐酸米诺环素软膏三联疗法对早期种植体周围炎控制的临床效果。方法    选择中国医科大学附属口腔医院牙周科2013年2月至2014年6月诊断为早期种植体周围炎的患者26例（40枚种植体），随机分为激光治疗组和对照组，每组各20枚种植体。对照组种植体接受机械治疗并局部应用盐酸米诺环素软膏。激光治疗组种植体在接受对照组治疗的基础上联合使用 Nd∶YAG激光治疗。分别在治疗前、治疗后8周检查两组种植体改良菌斑指数（modified plaque index，mPLI）、改良龈沟出血指数（modified sulcus bleeding index，mSBI）和探诊深度（probe depth，PD）。结果    两组治疗后与治疗前相比mPLI、mSBI、PD均显著改善（P < 0.05）。在治疗后8周，激光治疗组PD和mSBI牙周指数均显著低于对照组（均P < 0.05）。结论    采用机械治疗+ Nd∶YAG 激光+局部应用盐酸米诺环素软膏三联疗法治疗早期种植体周围炎能够取得更好的临床效果。

关键词: 种植体周围炎, 激光, 盐酸米诺环素