Abstract:

Objective　To assess the efficacy of oral propranolol combined with topical timolol maleate in the treatment of infantile parotid hemangiomas. Methods　Twenty-seven infants with parotid hemangiomas were hospitalized in Department of Oral and Maxillofacial Surgery， Hospital of Stomatology， China Medical University，from September 2013 to September 2015. The study group consisted of 9 males and 17 females， aged between 2 months to 9 months， with a median age of 4.8 months. The lesions were all located in the parotid region，and measured between 1.5 cm × 2.0 cm × 1.0 cm and 7.0 cm × 6.0 cm ×3.0 cm in size. Propranolol was administered orally at a dose of 1.0～1.5 mg/（kg·d）， 0.5% timolol maleate eye drop solution was applied topically with medical cotton swabs to the area of the lesion twice a day. The therapy duration was 12 to 32 weeks， averaged 20.3 weeks. The follow-up duration was from 3 months to 12 months， averaged 8.4 months. Record the colors， volumes， textures， and ultrasonic results of hemangiomas before the treatments and at the end of treatments. Results　Of the 27 patients，21 demonstrated an excellent response （77.8%），4 showed a good response （14.8%），and 2 displayed a moderate response （7.4%）；cure rate was 77.8%，and effective rate was 100%. Conclusion　Overall，oral propranolol combined with topical timolol maleate is an effective treatment method for infantile parotid hemangioma，and is worth promoting.

Key words: infantile hemangioma, propranolol, timolol maleate, parotid

摘要：

目的    评估口服普萘洛尔与局部外用马来酸噻吗洛尔联合应用治疗婴幼儿腮腺区血管瘤的效果。方法        选择2013年9月至2015年9月中国医科大学附属口腔医院口腔颌面外科收治的27例腮腺区血管瘤患儿。其中男8例，女19例；年龄2 ～ 9个月，平均年龄4.8个月。病灶大小1.5 cm × 2.0 cm × 1.0 cm ～ 7.0 cm × 6.0 cm × 3.0 cm。治疗采用普萘洛尔［1.0 ～ 1.5 mg/（kg·d）］每日1次口服，0.5%马来酸噻吗洛尔每日2次利用医用纱布外敷于病灶处。疗程12～32周，平均20.3周。随访时间为3～12个月，平均8.4个月。治疗前后记录瘤体颜色、体积、质地的变化，并完善病灶区的超声检查。结果    27例患儿中效果为“优”的21例（77.8%）、“好”的4例（14.8%）、“中”的2例（7.4%）、“差”的0例（0%）；治愈率77.8%，有效率100%。结论    口服普萘洛尔联合局部外用马来酸噻吗洛尔对于治疗婴幼儿腮腺区血管瘤具有很好的疗效，治疗方法值得推广。

关键词: 婴幼儿血管瘤, 普萘洛尔, 马来酸噻吗洛尔, 腮腺区