Abstract:

Abstract：Objective To investigate the effects of total flavone of epimedium（TFE） on the orthodontic tooth movement and the orthodontic periodontal tissue in the pressure side. Methods Totally 40 male Wister rats were chosen to establish orthodontic tooth movement model. The rats were randomly divided into 4 groups with ten in each. From the 1st day，in control group（group A），the rats were fed on saline，while TFE groups （group B，C and D） were fed on TFE with concentrations of 75，150，300 mg/（kg·d）. Ten days later，all rats were sacrificed. The distances of maxillary first tooth movement were measured and the periodontal remodeling were observed by histological evaluation. Results The distance of the orthodontic tooth movement in group A and B were of no statistic significance（P > 0.05）. The distance of the orthodontic tooth movement was significantly decreased in group C and D compared with group A （P＜0.05）. HE staining showed that the number of alveolar bone resorption lacunae of the TFE groups were inferior to the control group. Conclusion Total flavonoids of epimedium can inhibite the orthodontic tooth movement and alveolar bone resorption on the pressure side in rats. The role of TFE is more significant with its concentration increasing in a certain range.

Key words: total flavone of epimedium, orthodontic tooth movement

摘要：

目的 探讨淫羊藿总黄酮（TFE）对正畸大鼠牙齿移动及压力侧牙周组织的影响。方法 本研究于2012年9月至2013年4月在山西医科大学口腔医院进行。选取 8周龄雄性Wistar大鼠40只，建立正畸牙移动模型。按随机数字表法分为对照组（A组）和实验组（B、C、D组），每组10只。从正畸加力第1天开始，A、B、C、D组分别灌服不同剂量TFE（依次为0、75、150、300 mg/kg），每天1次，第10天处死全部大鼠。测量大鼠左上第一磨牙移动距离，HE染色观察其压力侧牙周组织变化。结果 A、B组牙齿移动距离差异无统计学意义（P＞0.05）；C、D组牙齿移动距离均明显小于A组（对照组），差异有统计学意义（均P＜0.05）。HE染色显示，实验组正畸牙齿压力侧骨吸收陷窝少于对照组。结论 TFE可抑制正畸大鼠牙齿移动及压力侧牙槽骨吸收，且在一定范围内，剂量越大作用越明显。

关键词: 淫羊藿总黄酮, 正畸牙齿移动