Abstract: Objective  To investigate the safety and efficacy of nebulized lidocaine in postoperative analgesia after oral soft tissue surgery. Methods　Forty patients requiring oral soft tissue surgery were randomly divided into two groups：lidocaine group and control group，20 in each group. After surgery，the patients in lidocaine group received 10 mL of 2% nebulized lidocaine and 10 mL of 0.9% saline was given to control group. The VAS pain score，the vital signs，the dosages of sufentanil and side effects were recorded. Results　There was no significant differences in VAS pain score between the two groups before application of nebulized lidocaine（P＞0.05）. The VAS pain score in the nebulized lidocaine group was significantly lower than that in the control group at 0.5，2 and 4 h after nebulization（P＜0.05）. Heart rate，systolic pressure and diastolic pressure did not differ between the two groups at any time point（P＞0.05）. Patients in the nebulized lidocaine group received lower dosage of sufentanil than those in the control group ［（9.00 ± 8.52）μg vs.（45.00 ± 13.18）μg，P < 0.05］. One patient in the nebulized lidocaine group suffered from nausea without vomiting. Four patients suffered from nausea，and one patient suffered from vomiting in the control group. Conclusion　Application of nebulized lidocaine is found to be safe and effective for postoperative analgesia. It can reduce the opiods dosage.

Key words: oral soft tissue surgery, nebulized lidocaine, postoperative analgesia

摘要： 目的　评价雾化吸入利多卡因在口腔软组织手术术后镇痛的安全性和有效性。方法　选择2018年8月至2019年8月于中国医科大学附属口腔医院择期行口腔黏膜软组织手术患者40例，随机分为研究组和对照组，每组20例。手术结束后研究组患者给予2%利多卡因10 mL雾化吸入，对照组患者给予生理盐水10 mL雾化吸入，记录两组患者不同时点（T0为雾化吸入开始时，T1～T3分别为雾化吸入后0.5、2、4 h）的疼痛视觉模拟量表（visual analogue scale，VAS）评分、生命体征、舒芬太尼用量以及不良反应发生情况，并进行组间比较。结果　两组患者比较，在T0时点疼痛VAS评分差异无统计学意义（P＞0.05）；在T1、T2和T3时点，研究组患者比对照组患者疼痛VAS评分明显更低，差异均有统计学意义（均P＜0.05）。两组患者各时点心率、收缩压和舒张压变化，差异均无统计学意义（均P＞0.05）。研究组患者术后24 h舒芬太尼用量（9.00 ± 8.52）μg，对照组患者术后24 h舒芬太尼用量（45.00 ± 13.18）μg，两组间比较差异有统计学意义（P＜0.05）。研究组有1例患者发生恶心，未有患者发生呕吐；对照组有4例患者发生恶心，1例患者发生呕吐。结论　在口腔软组织手术术后雾化吸入利多卡因是一种安全、有效的镇痛方式，能够明显降低阿片类镇痛药物的用量。

关键词: 口腔软组织手术, 雾化吸入利多卡因, 术后镇痛