Abstract: Objective　To evaluate the safety and efficacy of the combination of dezocine and lidocaine in inferior alveolar nerve block. Methods　A total of forty patients with inferior alveolar nerve block under going oral and maxillofacial surgery at the Stomatological Hospital of China Medical University from May to August 2019 were randomly divided into two groups. The trial group received 2% lidocaine 4 mL plus dezocine 0.2 mL（1 mg）；the control group received 2% lidocaine 4 mL plus saline 0.2 mL. The onset time of anesthesia，the duration of anesthesia，the effect of intraoperative analgesia and the complications were recorded. Results　The onset time of anesthesia in trial group ［（150.90 ± 24.92）s ］ was significantly shorter than that in control group ［（228.60 ± 28.47）s ］（P < 0.05）. The duration of anesthesia ［（3.49 ± 0.43）h ］ was significantly longer than that in control group ［（2.39 ± 0.31）h ］（P < 0.05）. There was no significant difference in the intraoperative analgesic effect between the two groups（P > 0.05）. One case in the trial group and one in the control group developed transient dizziness. Conclusion　The combination of dezocine and lidocaine is effective in inferior alveolar nerve block，which can effectively shorten the onset time of lidocaine and prolong the duration of anesthesia without increasing the incidence of adverse reactions，such as nausea，vomitting and drowsiness.

Key words: dezocine, lidocaine, inferior alveolar nerve block

摘要： 目的　评价地佐辛联合利多卡因在下牙槽神经阻滞麻醉中应用的安全性和有效性。方法　选取2019年5—8月于中国医科大学附属口腔医院口腔颌面外科行下牙槽神经阻滞麻醉患者40例，随机均分为2组。研究组麻醉药物选用2%利多卡因4 mL+地佐辛0.2 mL（1 mg），对照组麻醉药物选用2%利多卡因4 mL+生理盐水0.2 mL。记录麻醉起效时间、麻醉持续时间、术中镇痛效果及麻醉相关并发症。结果　研究组麻醉起效时间为（150.90 ± 24.92）s，对照组麻醉起效时间为（228.60 ± 28.47）s，其差异具有统计学意义（P < 0.05）；研究组麻醉持续时间（3.49 ± 0.43）h，对照组麻醉持续时间（2.39 ± 0.31）h，其差异具有统计学意义（P < 0.05）；两组术中镇痛效果的比较，差异无统计学意义（P > 0.05），且均有1例出现一过性头晕症状。结论　地佐辛联合利多卡因应用于下牙槽神经阻滞麻醉效果良好，能够有效缩短利多卡因起效时间，延长持续时间，并不会导致恶心、呕吐、嗜睡等不良反应的发生。

关键词: 地佐辛, 利多卡因, 下牙槽神经阻滞